贵州医科大学学报

2017, v.42;No.203(08) 872-875+892

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飞行员CX-37基因多态性与冠状动脉硬化的关系
Correlation Study on Pilots' Connexin-37 Gene Polymorphism and Coronary Atherosclerosis

牟宗阳;殷雪娇;刘兴德;罗惠兰;
MOU Zongyang;YIN Xuejiao;LIU Xingde;LUO Huilan;Guizhou Medical Univresity;Jinzhou Medical University;General Hospital of Air Force PLA;

摘要(Abstract):

目的:研究飞行员冠状动脉粥样硬化(AS)患者血清间隙连接蛋白37(CX-37)水平及CX-37基因-1019C>T位点的基因多态性与AS的关系。方法:选取确诊有AS的飞行员及普通人,健康飞行员和普通健康体检者,测定血清CX-37水平,比较4组受检者CX-37基因-1019C>T位点的基因型分布和等位基因的频率。结果:飞行员AS组及普通人AS组血清CX-37水平明显高于飞行员正常组及普通人正常组(P<0.05),但是普通人AS组与飞行员AS组CX-37水平比较,差异无统计学意义(P>0.05);4组CX-37基因-1019C>T位点CC、CT、TT基因型分布及等位基因频率比较,差异无统计学意义(P>0.05)。结论:飞行员的工作性质不影响血清CX-37的表达水平,CX-37基因-1019C>T位点基因多态性与AS发病无关。
Objective: To investigate the relationship between pilots' coronary atherosclerosis( AS),serum CX-37 level and CX-37 gene-1019C > T site polymorphism. Methods: Selecting atherosclerosis pilots,healthy people,healthy pilots,ordinary healthy subjects,testing their serum CX-37,and comparing CX-37 gene-1019C > T site geno-distribution and allele frequency of four groups. Results: The serum CX-37 level in AS pilot group and in healthy people AS group were significantly higher than those in pilot group and normal group( P < 0. 05); comparing CX-37 level of healthy people AS group and AS pilot group,differences were not statistically significant( P > 0. 05); comparing CX-37 gene-1019C > T site CC,CT and TT geno-distribution and allele frequency,differences were not statistically significant( P > 0. 05). Conclusion: The work itself of pilot has no effect on CX-37 expression,CX-37gene-1019C > T site polymorphism has no significant effect on coronary atherosclerosis.

关键词(KeyWords): 飞行员;缝隙连接蛋白质类;多态性,单核苷酸;冠状动脉疾病;动脉粥样硬化
pilot;connexin-37;polymorphism,mononucleotide;coronary artery diseases;atherosclerosis

Abstract:

Keywords:

基金项目(Foundation): 全军“十二五”重点基金资助项目(BWS11J054)

作者(Author): 牟宗阳;殷雪娇;刘兴德;罗惠兰;
MOU Zongyang;YIN Xuejiao;LIU Xingde;LUO Huilan;Guizhou Medical Univresity;Jinzhou Medical University;General Hospital of Air Force PLA;

Email:

DOI: 10.19367/j.cnki.1000-2707.2017.08.002

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