龚天兰,肖子文,薛爱存,邱芳,魏洪
GONG Tianlan,XIAO Ziwen,XUE Aicun,QIU Fang,WEI Hong

• 1:贵州医科大学附属医院妇科
• 2:贵州省骨科医院妇产科
• 3:贵州省人民医院妇科
• 4:贵州医科大学微生物学教研室

摘要(Abstract)：

目的 观察气腹条件下不同特伦伯格体位家兔颅内压力的变化及脑水肿情况。方法 36只普通级雌性新西兰兔均分为A、B、C组（A组平卧位、B组头低位20°、C组头低位30°），建立家兔CO_2气腹模型，在气腹后2、3及4 h测量家兔颅内压力，处死家兔后测量脑组织含水量，苏木素伊红（HE）染色观察脑组织学变化。结果 3组家兔的颅内压力、脑组织含水量随人工气腹后时间延长（2、3、4 h）呈上升趋势，A组 0.05）；随头低位角度增加，家兔颅内压力和脑组织含水量呈上升趋势，A组 0.05）。结论 气腹时间及T位的倾斜角度会影响家兔颅内压和脑水肿，但脑水肿的病理改变可能与气腹时间有关而与体位无关。
Objective To observe the changes of intracranial pressure and cerebral edema of rabbits in different Trendelenburg position( T position) under pneumoperitoneum.Methods Thirty-six female New Zealand rabbits of common grade were randomly divided into Group A, B, and C(Group A was supine, Group B had A low head position of 20 °, and Group C had A low head position of30 °)． The CO_2 pneumoperitoneum model of rabbits was established. Intracranial pressure was measured for 2 h, 3 h and 4 h after pneumoperitoneum. The pathological changes of brain tissues were observed by hematoxylin eosin(HE) staining. After data collection and processing, SPSS was used for statistical analysis of the data, while repeated measurement analysis of variance was used for statistical analysis of quantitative data of different groups at different time points, and LSD test was used for pair comparison of different groups.Results The intracranial pressure, dry weight, wet weight and water content of brain tissues in Group A, B and C were compared.(P< 0. 05), the dry weight and wet weight of experimental rabbits in the three groups showed no change trend with the passage at the 3time points(P> 0. 05), inter-group comparison: the intracranial pressure and brain tissue water content increased with the increase of low head angle(P< 0. 05). HE staining showed that there was a certain correlation between the pathological changes of cerebral edema and the time of pneumoperitoneum. The cerebral edema appeared in 3 h and was more obvious in 4 h, but it had no obvious correlation with the group.Conclusion Pneumoperitoneum time and T position are the independent factors affecting the intracranial pressure and cerebral edema of the rabbits, T a change along with the extension of time, the rabbit brain tissues of intracranial pressure and brain tissue water content is on the rise, the pathological results showed pathological changes of brain edema may be related to the length of time of pneumoperitoneum, and no obvious correlation with the position.

关键词(KeyWords)： 体位;气腹;脑水肿;颅内压;家兔
different body positions;pneumoperitoneum;brain edema;intracranial pressure;rabbits

Abstract:

Keywords:

基金项目(Foundation): 贵阳市科学技术局-贵州省骨科医院大健康科技合作项目（筑科合同[2019]9-5-11）

作者(Author): 龚天兰,肖子文,薛爱存,邱芳,魏洪
GONG Tianlan,XIAO Ziwen,XUE Aicun,QIU Fang,WEI Hong

DOI: 10.19367/j.cnki.2096-8388.2022.04.007

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