李靖,李莉艳,卢志强,周帅,牛方卿,黄克钧
LI Jing,LI Liyan,LU Zhiqiang,ZHOU Shuai,NIU Fangqing,HUANG Kejun

• 1:河南省胸科医院心九科

摘要(Abstract)：

目的:观察急性冠脉综合征(ACS)患者颈动脉斑块与血清白细胞介素-6(IL-6)和可溶性白细胞介素-6受体(s IL-6R)的关系。方法:85例ACS患者作为病例组,80例其它原因入院的冠心病患者作为对照组,彩色超声诊断仪检测颈动脉粥样斑块情况,ELISA法测定血清中的IL-6和s IL-6R水平,分析ACS患者颈动脉斑块稳定性与血清IL-6、s IL-6R水平的相关性。结果:病例组中具有颈动脉斑块不稳定斑块的患者比例明显高于对照组,差异具有统计学意义(P<0.05);病例组患者血清IL-6水平明显高于对照组,而s IL-6R水平明显低于对照组,差异有统计学意义(P<0.05);ACS患者血清IL-6水平与颈动脉斑块的不稳定性呈正相关关系(OR=3.85,P<0.05),ACS患者血清s IL-6R水平与颈动脉斑块的不稳定性呈负相关关系(OR=0.81,P<0.05)。结论:ACS患者IL-6和s IL-6R可作为预测ACS患者颈动脉粥样斑块稳定性的辅助指标。
Objective: To observe the relationship of carotid artery plaque of acute coronary syndrome( ACS) patients and serum levels of interleukin-6( IL-6) and soluble interleukin-6 receptor( s IL-6R). Methods: Eighty-five ACS patients were selected as case group,while 80 cases of hospitalized patients with coronary heart disease caused by other reasons were selected as control group. Color Doppler Ultrasonography( CDU) was used to detect carotid atherosclerotic plaque and serum IL-6 and s IL-6R levels were determined by ELISA. Then,the correlation of stability of carotid plaque and serum IL-6,s IL-6R levels of ACS patients was analyzed. Results: The proportion of unstable carotid artery plaque in case group was significantly higher than that in control group( P < 0. 05); The level of serum IL-6 in case group was significantly higher than that in control group,while the s IL-6R level was significantly lower than that in control group( P < 0. 05); There existed a positive correlation between the instability of carotid artery plaque and serum IL-6 levels( OR = 3. 85,P < 0. 05),while there existed a negative correlation between the instability of carotid artery plaque and serum s IL- 6R levels( OR = 0. 81,P < 0. 05). Conclusion: IL-6 and s IL-6R can be used as an auxiliary index for prediction of stability of carotid artery plaque of ACS.

关键词(KeyWords)： 急性冠脉综合征;颈动脉斑块;白细胞介素6;可溶性白细胞介素6受体
acute coronary syndrome;carotid artery plaque;interleukin-6;soluble interleukin-6 receptor

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 李靖,李莉艳,卢志强,周帅,牛方卿,黄克钧
LI Jing,LI Liyan,LU Zhiqiang,ZHOU Shuai,NIU Fangqing,HUANG Kejun

DOI: 10.19367/j.cnki.1000-2707.2015.01.017

参考文献(References)：

• [1]冯庚.心搏骤停系列讲座-急性冠脉综合征稳定期导致心搏骤停可能性的临床预测[J].中国全科医学,2008(11):2103-2104.
• [2]Zhou Y,Wang Y,Qiao S.Apelin:a potential marker of coronary artery stenosis and atherosclerotic plaque stability in ACS patients[J].Int Heart J,2014(3):204-212.
• [3]吴再涛,李玲,马贞枝,等.慢性心力衰竭患者血清CRP水平的变化及临床意义[J].中华全科医学,2010(11):1403-1404.
• [4]Chung H,Kwon HM,Kim JY,et al.Lipoprotein-associated phospholipase a2is related to plaque stability and is a potential biomarker for acute coronary syndrome[J].Yonsei Med J,2014(6):1507-1515.
• [5]Foo K,Cooper J,Deaner A,et al.A single serum glucose measurement predicts adverse outcomes across the whole range of acute coronary syndromes[J].Heart,2003(5):512-516.
• [6]王晓萍,吴蔚,邵冰,等.急性冠脉综合征患者临床特点及与心功能不全发生的关系[J].广东医学,2013(10):1526-1528.
• [7]史文举.炎性细胞因子与急性冠脉综合征关系的研究进展[J].中华保健医学杂志,2010(2):40-41.
• [8]Heeschen C,Dimmeler S,Hamm CW,et al.Pregnancy associated plasma protein-A levels in patients with acute coronary sydromes:comparison with markers of systemic infammation,platele cutivation and myocardial necrosis[J].J Am Coll Cardiol,2005(2):229-237.
• [9]Heeschen C,Dimmeler S,Hamm CW,et al.Soluble CD40 ligand in actue coronary syndromes[J].N Engl J Med,2003(12):1104-1111.
• [10]Cesari M,Penninx BW,Newman AB,et al.Inflammatory markers and onset of cardiovascular events results from the health ABC study[J].Circulation,2003(19):2317-2322.
• [11]王迪.超敏C反应蛋白与冠心病患者冠状动脉病变程度及预后的关系[J].实用临床医药杂志,2013(15):96-102.

文章评论(Comment)：