张金凤,王娇娇,李波,杨俊,崔玉霞,卢根,朱晓萍
ZHANG Jinfeng,WANG Jiaojiao,LI Bo,YANG Jun,CUI Yuxia,LU Gen,ZHU Xiaoping

• 1:贵州医科大学附院儿科
• 2:贵州省人民医院儿科
• 3:贵阳市儿童医院呼吸科

摘要(Abstract)：

目的:分析贵阳地区哮喘患儿血清过敏原特异性Ig E(SIg E)水平及哮喘过敏原种类分布。方法:350例哮喘患儿按年龄分为:婴幼儿组(<3岁)93例,学龄前组(3~6岁)120例和学龄组(7~15岁)137例,采用欧蒙印迹法(EUROLINE)检测各组患儿血清常规SIg E及过敏原组合,进一步分析吸入性SIg E与食入性SIg E的过敏原组合;比较3组患儿SIg E表达水平。用EUROLine Scan软件判定SIg E水平。结果:350例哮喘患儿SIg E阳性276例(78.85%),排列前四位的过敏原依次为尘螨组合、屋尘、狗上皮及淡水鱼组合;学龄前组及学龄组患儿吸入性过敏原SIg E阳性率明显高于婴幼儿组,差异有统计学意义(P<0.01);婴幼儿组及学龄前组患儿食入性过敏原SIg E阳性率明显高于学龄组,差异有统计学意义(P<0.05);学龄组SIg E阳性强度明显高于婴幼儿组和学龄前组(P<0.01);学龄组患儿过敏原尘螨SIg E强度明显高于婴幼儿组和学龄前组,3组间比较差异有统计学意义(P<0.01)。结论:尘螨是贵阳地区哮喘患儿的主要致敏原,学龄前期、学龄期患儿以吸入过敏原为主,婴幼儿以食入性过敏原为主。
Objective: To explore the category and distribution of specific Ig E level in children with asthma. Methods: A total of 350 cases of children patients with asthma were enrolled in this study,who were divided into infants and young children group( < 3 year-old,93 cases),pre-school group(3 ~ 6 year-old,120 cases) and school age group(7 ~ 15 year-old,137 cases). EUROLIN was adopted to detect serum specific Ig E level and allergen combination. Furthermore,inhalable specific Ig E and ingestive specific Ig E allergen combination were analyzed. The serum specific Ig E in 3 groups were compared and the specific Ig E levels were determined by EUROLine Scan software. Results: The positive cases of SIg E in 350 cases of children was 276(78. 85%). The 4 allergen that were most likely to occur were dust mite combination,house dust,dog dander and freshwater fish combination. The SIg E positive rates caused by inhalable allergen in pre-school group and school age group were significantly higher than their counterparts in infants and young children group( P < 0. 01). The SIg E positive rates caused by ingestive allergen in infants and young children group and pre-school group were significantly higher than their counterparts in school age group( P < 0. 05). The SIg E positive intensity of school age group was significantly higher than those of infants and young children group and preschool group( P < 0. 01). The SIg E positive intensity of school age group caused by dust mite allergen was significantly higher than those of infants and young children group and pre-school group,and the differences were statisticalyl significant between the three groups( P < 0. 01). Conclusion: Dust mites are the most important allergen in children with asthma in Guiyang. For pre-school and school age children,the reason for asthma is mainly inhalable allergen while for infants and young children the reason is mainly is ingestive allergen.

关键词(KeyWords)： 哮喘;支气管;儿童;过敏原;SIg E;贵阳
asthma;bronchus;children;allergen;SIg E;Guiyang

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅社会发展基金[黔科合SY(2010)3018号];; 贵阳市科技局社会发展领域科技攻关项目(2010筑科农合同字第1-社-23号)

作者(Author): 张金凤,王娇娇,李波,杨俊,崔玉霞,卢根,朱晓萍
ZHANG Jinfeng,WANG Jiaojiao,LI Bo,YANG Jun,CUI Yuxia,LU Gen,ZHU Xiaoping

DOI: 10.19367/j.cnki.1000-2707.2016.02.022

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