翟琦,陈英杰,宣佶,文卫,胡维杰
ZHAI Qi,CHEN Ying jie,XUAN Jie,WEN Wei,HU Weijie

• 1:东部战区总医院秦淮医疗区

摘要(Abstract)：

目的:探讨双歧杆菌三联活菌胶囊联合四联疗法治疗幽门螺杆菌(Hp)阳性慢性浅表性胃炎(CSG的疗效及对炎症-氧化应激水平的影响。方法:152例Hp阳性CSG患者均分为观察组与对照组,对照组采用标准四联疗法(雷贝拉唑钠肠溶胶囊+胶体果胶铋干混悬剂+克拉霉素缓释片+阿莫西林分散片)治疗,观察组在对照组基础上加用双歧杆菌三联活菌胶囊治疗,疗程均为2个月;于治疗结束时,比较2组患者临床治疗效果和Hp根除情况;比较治疗前及治疗结束时,检测2组患者血清核转录因子(NF-κB)、白细胞介素-4(IL-4)、IL-6、IL-8、IL-10、肿瘤坏死因子-α(TNF-α)等炎症指标及血清超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽(GSH-Px)]等氧化应激指标水平;比较随访6个月时2组患者的复发率。结果:治疗结束时,观察组患者总有效率(9868%)及Hp根除率(8947%)显著高于对照组(8816%、6974%),差异有统计学意义(P<005);治疗结束时,2组患者血清NF-κB、IL-4、IL-6、IL-8、TNF-α及MDA水平显著低于对照组,IL-10、SOD及GSH-Px显著高于治疗前,观察组变化更显著,差异有统计学意义(P<005);随访6个月时,观察组复发率(1067%)显著低于对照组(2687%),差异有统计学意义(P<005)。结论:双歧杆菌三联活菌胶囊联合四联疗法治疗Hp阳性CGS疗效优于单一标准四联疗法,能够抑制炎症反应和氧化应激损伤,降低复发风险。
Objective: To investigate the efficacy of bifidobacterium triple viable capsules combined with quadruple therapy for patients with Helicobacter. pylori(Hp)-positive chronic superficial gastritis and effects on inflammation-oxidative stress.Methods: From January 2017 to October 2018,152 patients withHp-positive CSG who admitted to our department were enrolled and randomly assigned to the observation group and the control group, with 76 cases in each group. Both groups were treated conventionally. The control group received standard quadruple therapy(rabeprazole sodium enteric coated capsule + colloidal pectin bismuth dry suspension + clarithromycin sustained release tablets +amoxicillin dispersible tablets), the observation group received bifidobacteria triple viable capsules therapy on the basis of the control group, the course of treatment was 2 months for both groups. At the end of treatment, the clinical efficacy andHperadication were compared between the two groups.Serum inflammation indicators [interleukin-4(IL-4), interleukin-6(IL-6), interleukin-8(IL-8),interleukin-10( IL-10), tumor necrosis factor-α ( TNF-α )] and oxidative stress indicators[superoxide dismutase(SOD), malondialdehyde(MDA), glutathione(GSH-Px)] were detected before and after treatment.Results: The total effective rate andHperadication rate of the observation group were 98.68% and 89.47%, higher than 88.16%, 69.74% of the control group(P< 0. 05).After treatment, the serum levels of NF-κB, IL-4, IL-6, IL-8, TNF-α and MDA in the observation group were lower than those in the control group, while IL-10, SOD and GSH-Px were higher than the control group(P< 0. 05). After 6 months of follow-up, the recurrence rate of the observation group was 10. 67%, which was lower than 26. 87% of the control group(P< 0. 05).Conclusion:Bifidobacterium triple viable capsules combined with quadruple therapy for the treatment ofHp-positive CGS is effective, which can inhibit inflammation and oxidative stress damage and reduce the risk of recurrence.

关键词(KeyWords)： 慢性浅表性胃炎;双歧杆菌三联活菌;四联疗法;临床疗效;炎症因子;氧化应激;复发
chronic superficial gastritis(CSG);bifidobacterium triple viable bacteria;quadruple therapy;clinical efficacy;inflammatory factors;oxidative stress;relapse

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学青年基金（81704196）;; 江苏省“333工程”培养项目(81704196)

作者(Author): 翟琦,陈英杰,宣佶,文卫,胡维杰
ZHAI Qi,CHEN Ying jie,XUAN Jie,WEN Wei,HU Weijie

DOI: 10.19367/j.cnki.1000-2707.2020.02.016

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