林晴晴,王鉴
LIN Qingqing,WANG Jian

• 1:贵州医科大学
• 2:贵州医科大学附院新生儿科

摘要(Abstract)：

目的:探讨宫外发育迟缓(EUGR)早产儿生化代谢指标的变化。方法:60例早产儿分为EUGR组及非EUGR组,于出生后7、14 d、3月龄、6月龄4个时间点测量两组早产儿的体格指标(体质量、身长、头围),并于同一时间点清晨取空腹外周静脉血检测清蛋白(ALB)、前清蛋白(PA)、胆固醇(TC)、三酰脂甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、INS、C肽、IGF-1,计算胰岛素抵抗指数(IRI)。结果:EUGR组7、14 d体质量低于非EUGR组,3月龄、6月龄体质量、头围、身长低于非EUGR组,体质量、头围及身长落后比例高于非EUGR组,差异有统计学意义(P<0.05);EUGR组7、14 d、3月龄、6月龄PA水平低于非EUGR组早产儿,3月龄、6月龄IGF-1水平低于非EUGR组,差异有统计学意义(P<0.05),两组新生儿PA、IGF-1水平随日龄增加有升高趋势;3月龄log INS高于非EUGR组,发生胰岛素抵抗(IR)的例数多于非EUGR组,差异有统计学意义(P<0.05)。结论:早产儿EUGR与PA水平、IGF-1水平和IR密切相关。
Objective: To investigate the changes of biochemical and metabolic indices in premature infants with extrauterine growth retardation( EUGR). Methods: Sixty premature infants are categorized into EUGR group and non-EUGR group. Physical indices( body weight,body length and head circumference) were detected in 7 d,14 d,3 and 6 months after birth,and at the same time fasting peripheral venous blood was drawn to examine the levels of albumin( ALB),prealbumin( PA),cholesterol( TC),triglyceride( TG),high density lipoprotein-cholesterol( HDL-C),low density lipoprotein-cholesterol( LDL-C),fasting blood glucose( FBG),insulin,C-peptide( CP),insulin-like growth factor( IGF-I),and insulin resistance index( IRI) was calculated. Results: The body weight of EUGR group infants was lower than non-EUGR group at 7 d and 14 d after birth( P < 0. 05); body weight,head circumference and body length of EUGR group infants were lower than non-EUGR group at 3 and 6 months after birth( P < 0. 05). The growth retardation rates of weight,head circumference and body length of EUGR group infants were higher than that of non-EUGR group at 3 and 6 months after birth( P < 0. 05). The level of PA of EUGR group was lower than that of non-EUGR group at 7 d,14 d,3 and 6 months after birth; the level of IGF-1 of EUGR group was lower than that of non-EUGR group at 3 and 6 months after birth( P < 0. 05),the levels of PA and IGF-1 of all the groups tended to increase along with age increasing. The level of INS of EUGR group was higher than that of non-EUGR group at 3 months after birth( P < 0. 05); Occurrence of insulin resistance( IR) in EUGR group was higher than non-EUGR group in 3 months after birth( P < 0. 05). Conclusions: The levels of PA、IGF-1 and IR are closely related to the EUGR of premature infant.

关键词(KeyWords)： 婴儿,早产,疾病;发育障碍;生化指标;代谢
infant,premature,disease;developmental disorder;biochemical index;metabolism

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅科学技术基金[黔科合J字(2009)2160号]

作者(Author): 林晴晴,王鉴
LIN Qingqing,WANG Jian

DOI: 10.19367/j.cnki.1000-2707.2017.04.018

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