贵州医科大学学报

2017, v.42;No.203(08) 969-973+978

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RFA联合IRIS化疗方案治疗胃癌术后肝转移的疗效及预后
Clinical Efficacy and Prognosis of Radiofrequency Ablation Combined with IRIS Chemotherapy for Gastric Cancer with Liver Metastasis

于广计;刘松;李强;王庆东;
YU Guangji;LIU Song;LI Qiang;WANG Qingdong;Department of Radiotherapy,Linyi Cancer Hospital;

摘要(Abstract):

目的:探讨射频消融(RFA)术联合伊立替康及替吉奥(IRIS)方案治疗胃癌术后肝转移患者的疗效及预后。方法:胃癌术后肝转移患者69例,39例为联合治疗组(采用RFA联合IRIS),30例为单纯化疗组(采用IRIS),按照实体瘤疗效评价标准(RECIST1.1)采用三期增强CT评价疗效,观察两组患者的不良反应;随访6.0~45.0个月,中位随访时间22.8个月,比较两组患者的无进展生存期和生存期,分析肿瘤的临床特征与预后的关系,比较两组不良反应发生率。结果:联合治疗组有效率为71.8%,单纯化疗组为43.3%,两组比较,差异有统计学意义(P<0.05);且联合治疗组1、2、3年的生存率及无进展生存期(PFS)高于单纯化疗组,差异均有统计学意义(P<0.05);两组化疗不良反应相似,差异无统计学意义(P>0.05)。结论:射频消融联合IRIS化疗方案治疗胃癌肝转移能提高治疗疗效,延长患者生存期,并发症及化疗毒副作用低,值得临床推广应用。
Objective: To investigate the clinical efficacy and prognosis of radiofrequency ablation( RFA) combined with irinotecan and S-1( IRIS regimen) for gastric cancer with liver metastasis.Methods: 69 patients with gastric cancer liver metastasis as research subjects,39 received RFA combined with IRIS regimen( combined treatment group) and 30 cases only received IRIS regimen( chemotherapy group). Adopting Triple-phase Enhanced CT to evaluate efficacy according to RECIST1. 1,observing adverse reaction of both groups; follow-up visits lasted 6. 0 to 45. 0 months,median visited time as 22. 8 months; comparing progression-free survival period and survival period of both groups,analyzing correlation between clinical features of tumor and prognosis; comparing adverse reaction incidence rate of both groups. Results: Effective rate of combined treatment group was 71. 8%,while chemotherapy group as 43. 3%,differences of both groups showed statistical significance( P < 0. 05);survival rate of 1,2,3 year and PFS of combined treatment group were higher than chemotherapy group,differences showed statistical significance( P < 0. 05). Adverse reaction of chemotherapy of both groups were similar,differences were not statistically significant( P > 0. 05). Conclusion: RFA combined with IRIS chemotherapy treatment for gastric cancer with liver metastasis can improve curative effect and prolong the survival period,lower complications and side effects of chemotherapy,which should be worthy of clinical popularizing.

关键词(KeyWords): 胃肿瘤;肝肿瘤;消融术;药物疗法,联合;伊立替康;替吉奥
stomach neoplasms;liver neoplasms;catheter ablation;drug therapy,combination;irinotecan;tegafur

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作者(Author): 于广计;刘松;李强;王庆东;
YU Guangji;LIU Song;LI Qiang;WANG Qingdong;Department of Radiotherapy,Linyi Cancer Hospital;

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DOI: 10.19367/j.cnki.1000-2707.2017.08.023

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