刘欣,陆迎春
LIU Xin,LU Yingchun

• 1:宝山区大场医院眼科

摘要(Abstract)：

目的:探索2型糖尿病(T2DM)患者视网膜病变的危险因素。方法:选取接受治疗的T2DM患者184例,92例发生视网膜病变患者作为观察组,观察组中46例增值性视网膜病变患者作为PDR组、46例背景型视网膜病变患者作为BDR组,未发生视网膜病变T2DM患者92例作为对照组;观察对照组和观察组患者的收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、肌酐(CRE)及总胆固醇水平(TCHO),并对BDR组和PDR组患者的SBP、DBP、年龄、FBG、病程进行比较;采用多因素Logistic回归法分析引起T2DM视网膜病变的相关危险因素。结果:对照组和观察组比较,高血压病史、患T2DM程比较,差异有统计学意义(P<0.05);观察组FBG、CRE指标于对照组,差异有统计学意义(P<0.05);PDR组的SBP、DBP均高于BDP组,BDR组患者的年龄高于PDR组,差异有统计学意义(P<0.05);糖尿病患者病程、TCHO、CRE及FBG与T2DM患者视网膜病变密切相关,FBG和患者病程是造成T2DM患者视网膜病变的独立危险因素。结论:糖尿病患者病程、TCHO、CRE及FBG与T2DM患者视网膜病变密切相关,FBG和患者病程是造成T2DM患者视网膜病变的独立危险因素。
Objective:To investigate the risk factors affecting retinopathy in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 184 patients with type 2 diabetes who were treated in our hospital from February 2013 to April 2016 were selected as study objects.Among them,92 patients without retinopathy as control group(group C),and the other 92 with retinopathy as observation group(group O),of which 46 patients had proliferative retinopathy(group PDR),and 46 cases were suffering retinal pigmentosis(group BDR).Systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood-glucose(FBG),creatinine(CRE),and total cholesterol(TCHO) of patients were tested and monitored and compared among groups.SBP,DBP,patient age,FBG and disease course were compared between groups PDR and BDR.Multi-factor logistic regression analysis was adopted for screening related risk factors.Results:The history of coronary heart disease,smoking history,and drinking history did not differ between groups O and C(P > 0.05).However,the history and course of hypertension and T2DM of groups O and C differed significantly.The indexes of FBG and CRE in group O were significantly different from those in group C(P < 0.05).SBP and DBP in group PDR were higher than those in group BDR,and patients in group BDR were older than patients in group PDR.The differences were significant(P < 0.05).Conclusion:The course of diabetic,TCHO,CRE,and FBG are closely correlated with retinopathy.Specially,FEG and diabetic course were independent risk factors that cause retinopathy in T2DM patients.

关键词(KeyWords)： 糖尿病2型;糖尿病视网膜病变;相关因素;血糖;空腹;病程;血脂
type 2 diabetes mellitus;diabetic retinopathy;related factors;blood blucose;fasting;disease course;blood lipid

Abstract:

Keywords:

基金项目(Foundation): 宝山区卫生青年医学人才培养专项资助(BSWSYQ-2014-A10)

作者(Author): 刘欣,陆迎春
LIU Xin,LU Yingchun

DOI: 10.19367/j.cnki.1000-2707.2018.02.022

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