贵州医科大学学报

2018, v.43;No.218(11) 1301-1305

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

不同基因型地中海贫血孕妇妊娠早期部分血常规指标分析
Detection of Early Blood Outcomes in Pregnant Women with Different Genotypes of Thalassemia

刘洋;王飞清;刘燕青;李红日;李艳菊;
LIU Yang;WANG Feiqing;LIU Yanqing;LI Hongri;LI Yanju;Department of Clinical Laboratory,the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine;Department of Hematology,the Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:探讨贵州省同基因型地中海贫血孕妇妊娠早期部分血常规检测结果差异。方法:330例年龄为20~35岁,孕3月产检确诊地中海贫血孕妇作为研究组,同期、同年龄段同孕期100例孕妇为对照组;采用PCR及导流杂交法检测确认研究组地中海贫血基因型,全自动血细胞仪检测两组受检者血液红细胞数量(RBC)、血红蛋白浓度(Hb)、平均红细胞体积(MCV)、平均红细胞血红蛋白量(MCH)、红细胞平均血红蛋白浓度(MCHC)及白细胞(WBC)计数。结果:缺失型α-地中海贫血孕妇(-α3. 7、--SEA、-α4. 2) RBC均高于对照组,Hb、MCV、MCH、MCHC均低于对照组,但只有--SEA基因型孕妇RBC、Hb、MCV、MCH与对照组比较差异有统计学意义(P <0. 05);突变型α-地中海贫血孕妇(αCS、αWS、αQS) RBC均高于对照组,Hb、MCV、MCH、MCHC均低于对照组,但只有αQS基因型孕妇RBC、MCV、MCH与对照组比较差异有统计学意义(P <0. 05);突变型β-地中海贫血孕妇(CD41/42、CD17、IVS-II-654、-28、CD27/28、CD43) RBC均高于对照组,但只有IVS-II-654、CD27/28基因型孕妇RBC与对照组比较差异有统计学意义(P <0. 05); Hb、MCV、MCH、MCHC均低于对照组,但只有CD41/42、CD17、IVS-II-654、-28、CD27/28基因型孕妇Hb明显低于对照组,差异有统计学意义(P <0. 05); CD41/42、CD17、IVS-II-654、-28、CD27/28基因型孕妇MCV、MCH明显低于对照组,差异有统计学意义(P <0. 05)。结论:不同基因型地中海贫血孕妇血液RBC、Hb、MCV、MCH、MCHC存在差异。
Objective: To investigate the difference of blood routine test results in early pregnancy of women with homogeneic thalassemia in guizhou province. Methods: 330 patients aged 20 ~ 35 years and diagnosed to be thalassemia in 3 months of pregnancy were selected as a study group; while 100 pregnant women with normal gestational age of 3 months in the same age group were randomly selected as control group. The genotype of thalassemia was confirmed by PCR and diversion hybridization;RBC,Hb,MCV,MCH,MCHC and WBC were detected by automatic blood cell analyzer. Results:The deletion type of alpha thalassemia patients(-α3. 7、--SEA、-α4. 2) RBC were higher than the control group,Hb,MCV,MCH and MCHC were lower than the control group;--SEA genotype pregnant women RBC,Hb,MCV and MCH were compared with those of the control group,the difference was statistically significant(P < 0. 05). The mutant alpha thalassemia pregnant women(αCS、αWS、αQS)RBC were higher than the control group; αQS genotype pregnant women RBC,MCV and MCH were compared with those of the control group,the difference was statistically significant(P < 0. 05). The mutant beta thalassemia pregnant women(CD41/42,CD17,IVS-II-654,-28,CD27/28,CD43)RBC were higher than the control group; IVS-II-654 and CD27/28 genotype pregnant women RBC were compared with those of the control group,the difference was statistically significant(P < 0. 05).Hb,MCV,MCH,MCHC were lower than the control group,CD41/42,CD17,CD27/28 genotype of pregnant women Hb was significantly lower than those of the control group,the difference was statistically significant(P < 0. 05). And CD41/42,CD17,ivs-ii-654,-28,and cd27/28 pregnant women MCV and MCH were significantly lower than those of the control group,and the difference was statistically significant(P < 0. 05). Conclusion: The blood levels of RBC,Hb,MCV,MCH,MCHC and WBC in pregnant women with different genotypes of thalassemia were significantly different.

关键词(KeyWords): 地中海贫血;基因;孕妇;血常规
thalassemia;gene;pregnant women;blood routine test

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(31660326);; 贵州省科技厅资助项目[黔科合基础(2016)1019]

作者(Author): 刘洋;王飞清;刘燕青;李红日;李艳菊;
LIU Yang;WANG Feiqing;LIU Yanqing;LI Hongri;LI Yanju;Department of Clinical Laboratory,the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine;Department of Hematology,the Affiliated Hospital of Guizhou Medical University;

Email:

DOI: 10.19367/j.cnki.1000-2707.2018.11.012

参考文献(References):

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享