贵州医科大学学报

2015, v.40;No.177(06) 641-643

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冠心病合并糖尿病患者血清淀粉样蛋白A及C反应蛋白的水平
Serum Levels of Amyloid Protein A and C Reactive Protein in Coronary Heart Disease Combined with Diabetes Mellitus

何建媚;
HE Jianmei;Worker's Hospital of Xuanhua Iron and Steel Corp of Iron and Steel Group in Hebei Province;

摘要(Abstract):

目的:探讨冠状动脉心脏病(CHD)合并糖尿病(DM)患者血清淀粉样蛋白A(SAA)及C反应蛋白(CRP)的表达。方法:选取经冠状动脉造影术(CAG)确诊为CHD的患者100例,其中合并DM患者42例为A组,单纯CHD患者58例为B组,同期经CAG排除CHD的患者30例为对照组,用双抗体夹心酶联免疫吸附试验(ELISA)测定血清SAA水平,速率散射比浊法测定CRP水平,并与冠脉Gensini评分进行相关性分析。结果:A组患者血清SAA明显高于B组及对照组,A、B组血清CRP水平显著高于对照组,差异有统计学意义(P<0.05);A、B组血清CRP水平比较,差异无统计学差异(P>0.05);SAA与冠脉Gensini评分呈正相关(r=0.738,P<0.05),SAA与CRP两者呈成正相关性(r=0.815,P<0.05)。结论:SAA、CRP对CHD合并DM的病情及其预后具有一定的预测价值。
Objective: To observe the serum levels of amyloid protein A( SAA) and C-reactive protein( CRP) in the patients with coronary heart disease( CHD) combined with diabetes mellitus( DM). Methods: A total of 100 CHD patients confirmed by coronary heart angiography( CAG) were enrolled in this study,among which 42 patients were combined with DM( group A) and 58 patients were purely suffered from CHD( group B). The double antibody sandwich ELISA and rate nephelometry were used to detect the serum levels of SAA and CRP. The correlation of serum levels of SAA and CRP with coronary Gensini scores was analyzed. Results: The level of SAA in group A was significantly higher than that in group B and control group( P < 0. 05). The CRP level in groups A and B was significantly higher than that in the control group( P < 0. 05). The difference of CRP level between groups A and B was not statistically significant( P > 0. 05). SAA and CRP levels were positively correlated with Gensini scale( r = 0. 738,P < 0. 05),and SAA level was positively correlated with and CRP level( r = 0. 815,P < 0. 05). Conclusions: SAA and CRP levels can finely predicate the condition and prognosis of CHD combined with DM.

关键词(KeyWords): 冠心病;糖尿病;血清淀粉样蛋白A;C反应蛋白;冠状动脉Gensini评分
coronary heart disease;diabetes mellitus;serum amyloid A;C-reactive protein;coronary antery Gensini scores

Abstract:

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基金项目(Foundation): 河北钢铁集团科学技术项目,编号:2010GT320-03

作者(Author): 何建媚;
HE Jianmei;Worker's Hospital of Xuanhua Iron and Steel Corp of Iron and Steel Group in Hebei Province;

Email:

DOI: 10.19367/j.cnki.1000-2707.2015.06.025

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