尹文艳,苏守硕,王菲,靳蓉,韩芳
YIN Wenyan,SU Shoushuo,WANG Fei,JIN Rong,HAN Fang

• 1:贵阳市儿童医院儿科

摘要(Abstract)：

目的:探讨支气管哮喘儿童尘螨过敏及特异性免疫治疗对呼出气一氧化氮(FeNO)水平的影响。方法:选取支气管哮喘患儿149例,根据过敏原检测结果将患儿分为尘螨过敏组91例和非尘螨过敏组58例,两组患儿在慢性持续期均给予糖皮质激素吸入、哮喘急性发作时均给予对症治疗,91例尘螨过敏患儿中有60例在吸入激素基础上联合屋尘螨皮下特异性免疫治疗,疗程均为1年,比较两组患儿治疗前后FeNO值,同时观察尘螨过敏组中经激素联合特异性免疫治疗患儿与单纯激素治疗患儿FeNO值。结果:治疗前,尘螨过敏组FeNO值显著高于非尘螨过敏组,差异有统计学意义(P<0.01);所有患儿经治疗后FeNO值均有不同程度降低,治疗前后相比,差异均有统计学意义(P<0.01);尘螨过敏组中经激素及特异性免疫治疗患儿FeNO水平低于单纯激素治疗患儿,差异有统计学意义(P<0.01)。结论:尘螨过敏哮喘患儿FeNO水平高于非尘螨过敏哮喘患儿,糖皮质激素联合特异性免疫治疗能使尘螨过敏哮喘患儿FeNO水平显著下降。
Objective:To investigate the effect of levels of nitric oxide(FeNO) in exhaled breath after specific immunotherapy in children with dust mite allergy asthma.Methods:149 children with bronchial asthma were divided into two groups:dust mite allergy group(n = 91) and non-dust mite allergy group(n = 58) according to the results of allergen test.The children in both groups were given glucocorticoid inhalation during the chronic duration and symptomatic treatment during acute asthma attack.Among 91 children with dust mite allergy,60 cases were treated with subcutaneous specific immunotherapy on the basis of inhaling hormone,andthe course of treatment was one year.The FeNO values of the two groups were compared before and after treatment.At the same time,the FeNO values were observed in children with dust mites allergy and in children with hormone combined specific immunotherapy and simple hormone treatment.Result:Before treatment,the FeNO value in the dust mite allergy group was significantly higher than that of the non-dust mite allergy group.The difference was statistically significant(P < 0.01).The FeNO values of all children were reduced to different degrees after treatment,and the difference was statistically significant before and after the treatment(P < 0.01).The level of FeNO in the allergic group of dust mite was lower than that in the group treated by hormone and specific immunotherapy,and the difference is statistically significant(P < 0.01).Conclusion:FeNO level of dust mite allergic asthma children is higher than that of non-dust mite allergic asthma children,and glucocorticoid combined with specific immunotherapy can significantly decrease FeNO level in children with dust mite allergic asthma.

关键词(KeyWords)： 哮喘;儿童;尘螨;过敏;呼出气一氧化氮;特异性免疫治疗
asthma;children;dust mite;allergy;nitric oxide in exhaled breath;specific immunotherapy

Abstract:

Keywords:

基金项目(Foundation): 贵阳市卫生局科研基金[(2009)450]

作者(Author): 尹文艳,苏守硕,王菲,靳蓉,韩芳
YIN Wenyan,SU Shoushuo,WANG Fei,JIN Rong,HAN Fang

DOI: 10.19367/j.cnki.1000-2707.2018.02.017

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