郝雅芳
HAO Yafang

• 1:房山区第一医院呼吸科

摘要(Abstract)：

目的:探讨慢性阻塞性肺疾病(COPD)患者外周血T淋巴细胞水平与肺功能的相关性。方法:242例COPD患者按病情严重程度分为COPDⅠ、Ⅱ、Ⅲ、Ⅳ级,58例健康体检者作为对照组,测定所有入组者的一秒用力呼气容积占预计值的百分比(FEV_1/Pre)、一秒用力呼气容积占用力肺活量的百分比(FEV_1/FVC),检测总T淋巴细胞百分比(CD3~+)、辅助性T细胞百分比(CD4~+)、杀伤性T细胞百分比(CD8~+)及辅助与杀伤细胞比值(CD4~+/CD8~+),分析COPD各期患者FEV_1/Pre、FEV_1/FVC与CD3~+、CD4~+、CD8~+数量及CD4~+/CD8~+的相关性。结果:随着COPD病情加重,FEV_1/Pre及FEV_1/FVC比值呈明显下降趋势(P<0.05),CD3~+、CD4~+细胞百分比及CD4~+/CD8~+比值随着COPD严重程度的增加而逐渐减少,CD8~+细胞数量随着COPD严重程度的增加而呈上升趋势;各级COPD患者的CD3~+、CD4~+细胞数量与FEV_1/Pre、FEV_1/FVC具有正相关性(P<0.05);COPDⅠ、Ⅱ、Ⅲ级患者CD8~+细胞数量与FEV_1/Pre、FEV_1/FVC具有负相关性(P<0.05),CD4~+/CD8~+比值与FEV_1/Pre、FEV_1/FVC具有正相关性(P<0.05)。结论:COPD患者外周血CD3~+、CD4~+及CD8~+细胞数量与肺功能存在明显的相关关系,CD3~+、CD4~+及CD8~+细胞数量可作为判断COPD患者病情严重程度和预后的指标。
Objective: To investigate the correlation between peripheral blood T cells and pulmonary function in patients with COPD. Methods: 242 patients with COPD were divided into COPD Ⅰ,Ⅱ,Ⅲ and Ⅳ according to the severity of the disease. 58 healthy persons were selected as the control group. The forced expiratory volume in one second/predicted value( FEV_1/Pre) and the forced expiratory volume in one second/forced vital capacity( FEV_1/FVC) were measured in all participants. Percentage of total T cells( CD3~+),auxiliary T cells( CD4~+),lethality T cells( CD8~+) and auxiliary T cells/lethality T cells( CD4~+/CD8~+) were detected,also the correlation between FEV_1/Pre,FEV_1/FVC and CD3~+,CD4~+,CD8~+,CD4~+/CD8~+in COPD patients at each stage was analyzed. Results:With the increase of the severity of COPD,the ratio of FEV_1/Pre and FEV_1/FVC showed a downward trend( P < 0. 05),percentage of CD3~+and CD4~+cells and ratio of CD4~+/CD8~+gradually decreased,and the number of CD8~+cells showed an upward trend. There was a positive correlation between CD3~+and CD4~+cells and FEV_1/Pre and FEV_1/FVC in COPD patients at each stage( P <0. 05). There was a negative correlation between the number of CD8~+cells and FEV_1/Pre、FEV_1/FVC in COPD patients at stage Ⅰ,Ⅱ and Ⅲ( P < 0. 05). The ratio of CD4~+/CD8~+was positively correlated with FEV_1/Pre and FEV_1/FVC( P < 0. 05). Conclusion: There was a significant correlation between the number of peripheral blood CD3~+,CD4~+and CD8~+cells and pulmonary function in patients with COPD. The severity of the disease and the prognostic index of patients with COPD were determined by Detecting the number of CD3~+,CD4~+and CD8~+cells might be the indexes of severity of the disease and prognosis of the patients with COPD.

关键词(KeyWords)： 肺疾病,慢性阻塞性;肺功能;T淋巴细胞亚群;T淋巴细胞计数
pulmonary disease,chronic obstructive;pulmonary function;subgroup of T cells;T cells counting

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 郝雅芳
HAO Yafang

DOI: 10.19367/j.cnki.1000-2707.2018.08.025

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