唐青蓝,李红梅,王剑青,管亚慧,雷霆雯,许庆忠
TANG Qinglan,LI Hongmei,WANG Jianqing,GUAN Yahui,LEI Tingwen,XU Qingzhong

• 1:贵阳医学院生物化学与分子生物学教研室
• 2:贵阳医学院附院
• 3:贵阳市第一人民医院

摘要(Abstract)：

目的:探讨血清成纤维细胞生长因子21(FGF21)与原发性高血压的相关性。方法:实验分为3组,原发性高血压伴动脉粥样硬化组(n=10)、原发性高血压非动脉粥样硬化组(n=20)及健康对照组(n=30),采用酶法测定血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,采用酶联免疫法测定血清FGF21及氧化-低密度脂蛋白(ox-LDL)水平,分析FGF21与脂代谢指标的相关性。结果:原发性高血压伴动脉粥样硬化组和原发性高血压非动脉粥样硬化组血清FGF21水平均明显高于对照组(P<0.05);线性相关分析显示血清FGF21水平与ox-LDL及TG水平均呈正相关。结论:原发性高血压患者FGF21水平升高,且FGF21水平的改变与ox-LDL及TG水平有关。
Objective: To investigate the correlation between serum fibroblast growth factor 21(FGF21) and essential hypertension.Methods: Thirty in-patients of essential hypertension were divided into two groups,essential hypertension with atherosclerosis group(group A,n = 10) and essential hypertension without atherosclerosis group(group N,n = 20).Thirty healthy people were chosen as healthy control group(group C).The levels of serum TG,TC,HDL-C and LDL-C were measured with a full automatic biochemical analyzer.The expression of serum FGF21 and ox-LDL was respectively determined by enzyme-linked immunosorbent assay(ELISA).Results: The serum FGF21 levels were both significantly higher in groups A and N than that in group C(P < 0.05);FGF21 was positively correlated with ox-LDL and TG.Conclusions: The serum FGF21 levels of essential hypertension patients were significantly higher than that of healthy people;FGF21 was positively correlated with oxLDL and TG,and the elevation of FGF21 level is closely associated with essential hypertension.

关键词(KeyWords)： 成纤维细胞生长因子;脂蛋白类,LDL;高血压;动脉硬化
fibroblast growth factors;lipoproteins,LDL;hypertension;arteriosclerosis

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅联合基金项目,黔科合LG字[2011]012号;; 贵阳医学院研究生教育创新计划专项经费资助项目(S201109)

作者(Author): 唐青蓝,李红梅,王剑青,管亚慧,雷霆雯,许庆忠
TANG Qinglan,LI Hongmei,WANG Jianqing,GUAN Yahui,LEI Tingwen,XU Qingzhong

DOI: 10.19367/j.cnki.1000-2707.2013.04.008

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