崔佳,郭莹,刘巧,丁秀丽
CUI Jia,GUO Ying,LIU Qiao,DING Xiuli

• 1:河北省人民医院
• 2:秦皇岛市妇幼保健院
• 3:秦皇岛市卫生学校
• 4:解放军第二五一医院

摘要(Abstract)：

目的:探讨产妇血清抗心磷脂抗体(ACA)和抗β2-糖蛋白1(β2-GP1)抗体与不良妊娠结局的关系。方法:选取不良妊娠产妇130例作为研究组,同期正常分娩产妇130例作为对照组;采用酶联免疫吸附法(ELISA)检测2组产妇血清ACA及各亚型(ACA-IgA、ACA-IgG、ACA-IgM)、β2-GP1抗体及各亚型(抗β2-GP1-IgA、抗β2-GP1-IgG、抗β2-GP1-IgM)水平,并分析这些指标与围产儿死亡的相关性。结果:研究组产妇血清ACA-IgG与ACA-IgM阳性率明显高于对照组(P<0.01),抗β2-GP1-IgG及β2-GP1-IgM阳性率明显高于对照组(P<0.01);研究组产妇血清ACA、抗β2-GP1抗体及联合检查阳性率均明显高于对照组,差异均具有统计学意义(P<0.01);研究组产妇血清抗ACA-IgA、抗β2-GP1-IgA、抗β2-GP1-IgM抗体水平与围产儿死亡具有相关性(r=0.312 6、P=0.018,r=0.307 8、P=0.007,r=0.401 2、P=0.021)。结论:血清ACA各亚型及抗β2-GP1各亚型抗体检测可用于评估不良妊娠结局。
Objective: To investigate the relationship between maternal serum anticardiolipin antibody(ACA) and anti-β2-GP1 antibody(β2-GP1) and adverse pregnancy outcomes. Methods: 130 cases of adverse pregnancy were selected as study group, and during the same period, 130 cases of normal delivery were used as control group. Enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of the two groups of maternal serum ACA and its subtypes(ACA-IgA, ACA-IgG and ACA-IgM), β2-GP1 antibodies and the level of subtypes(anti-β2-GP1-IgA, anti-β2-GP1-IgG, anti-β2-GP1-IgM)to analyze the correlation between these indicators and perinatal mortality. Results: The positive rate of serum ACA-IgG and ACA-IgM in the study group was significantly higher than that in the control group(P<0.01), and the anti-β2-GP1-IgG and positive rate of β2-GP1-IgM was significantly higher than that of control group(P<0.01). The positive rate of serum ACA, anti-β2-GP1 antibody and combination test were significantly higher than those of control group, and the differences were statistically significant(P<0.01). The serum levels of anti-ACA-IgA, anti-β2-GP1-IgA and anti-β2-GP1-IgM were correlated with perinatal death in the study group(r=0.312 6,P=0.018,r=0.307 8,P=0.007,r=0.401 2 and P=0.021). Conclusion: serum ACA subtypes and anti-β2-GP1 subtype antibody detection can be used to evaluate the outcomes of adverse pregnancy.

关键词(KeyWords)： 妊娠结局;抗心磷脂抗体;抗β2-糖蛋白1抗体;检测指标;阳性率;酶联免疫吸附法
pregnancy outcome;anticardiolipin antibody;anti-β2-glycoprotein 1 antibody;detection index;positive rate;enzyme-linked immunosorbent assay

Abstract:

Keywords:

基金项目(Foundation): 河北省医学科学研究课题项目(20190329)

作者(Author): 崔佳,郭莹,刘巧,丁秀丽
CUI Jia,GUO Ying,LIU Qiao,DING Xiuli

DOI: 10.19367/j.cnki.1000-2707.2020.01.017

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