贵州医科大学学报

2016, v.41;No.192(09) 1010-1014+1020

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云南汉族人群HSPA1A基因多态性位点与肺癌的相关性研究
The Association of SNPs in HSPA1A Gene with Lung Cancer in Yunnan Han Population

张新文;李盈甫;史荔;马千里;洪超;王婷婷;俞建昆;李传印;姚宇峰;杨慧娟;
ZHANG Xinwen;LI Yingfu;SHI Li;MA Qianli;HONG Chao;WANG Tingting;YU Jiankun;LI Chuanyin;YAO Yufeng;YANG Huijuan;Institute of Medical Biology,Chinese Academy of Medical Sciences & Peking Union Medical College,Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease;The First Affiliated Hospital of Kunming Medical University;The Third Affiliated Hospital of Kunming Medical University;

摘要(Abstract):

目的:探讨HSPA1A基因多态性与肺癌发生发展的相关性。方法:选取云南地区汉族人群肺癌患者288例为病例组,健康体检人群298例为对照组,采用Taq Man探针基因分型方法对HSPA1A基因中的4个多态性位点(SNPs)位点rs12190359(C>T)、rs562047(C>G)、rs1008438(G>T)及rs1043618(G>C)进行基因分型,研究其等位基因、基因型及所构建的单倍型在两组人群中分布差异。结果:2组人群rs1043618(G>C)等位基因C和G的分布频率差异有统计学意义(P=0.038),其中等位基因C是肺癌发生的保护性因素[OR=0.767;95%CI(0.597~0.986)];rs12190359(C>T)、rs562047(C>G)和rs1008438(G>T)的等位基因和基因型的分布差异无统计学意义(P>0.05);rs12190359与rs1008438(G>T)以及rs562047(C>G)与rs11043618(G>C)的单倍型在2组间分布频率差异无统计学意义(P>0.05)。结论:HSPA1A基因rs1043618(G>C)等位基因C可能是云南汉族肺癌发生的保护性因素。
Objective: To explore the association of four single nucleotide polymorphisms( SNPs)rs12190359 C > T,rs562047 C > G,rs1008438 G > T and rs1043618 G > C in HSPA1 A gene with the lung cancer in a Yunnan Han population. Method: A total 288 patients with lung cancer and 298 healthy individuals were recruited in this study,and the genotyping of above-mentioned four SNPs was analyzed by Taqman assay. The distribution of alleles,genotypes and constructed haplotypes in the two groups was studied. Result: There were statistically significant differences in distribution frequency of alleles G and C of rs1043618 G > C were significantly different between case and control groups( P =0. 038),and allel C was a protective factor of lung cancer[OR = 0. 767; 95% CI( 0. 597 ~ 0. 986) ].There were no statistically significant differences in distribution of the allele and genotype of rs12190359 C > T,rs562047 C > G and rs108438 G > T between the case group and control group( P> 0. 05). There were no statistically significant differences in the distribution frequencies of haplotypes of rs12190359 and rs1008438( G > T),rs562047( C > G) and rs11043618( G > C) between case and control groups( P > 0. 05). Conclusion: The C allele of rs1043618 G > C in HSPA1 A gene may be a protection factor of lung cancer,and the other sites may be not related to occurrence occurrence of lung cancer.

关键词(KeyWords): 肺肿瘤;HSPA1A;单核苷酸多态性;相关性;汉族;云南
lung cancer;HSPA1A;single nucleotide polymorphism;association;Han nationality;Yunnan province

Abstract:

Keywords:

基金项目(Foundation): 国家自然基金项目(31270030和81573206);; 协和青年基金(3332015149);; 云南省应用基础研究重点项目(2016FA034);; 云南省科技厅-昆明医科大学应用基础研究联合专项(2013FB169);; 中国医学科学院病原生物学研究所基本科研业务费项目(2012IPB107)

作者(Author): 张新文;李盈甫;史荔;马千里;洪超;王婷婷;俞建昆;李传印;姚宇峰;杨慧娟;
ZHANG Xinwen;LI Yingfu;SHI Li;MA Qianli;HONG Chao;WANG Tingting;YU Jiankun;LI Chuanyin;YAO Yufeng;YANG Huijuan;Institute of Medical Biology,Chinese Academy of Medical Sciences & Peking Union Medical College,Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease;The First Affiliated Hospital of Kunming Medical University;The Third Affiliated Hospital of Kunming Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2016.09.005

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