贵州医科大学学报

2019, v.44;No.225(06) 647-652+657

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下颌升支截骨术加速正畸牙移动的实验研究
Experimental Study on Acceleration of Orthodontic Tooth Movement by Mandibular Ramus Osteotomy

谭俭琴;唐正龙;李永頔;王冬香;陈友利;高琼;董强;
TAN Jianqin;TANG Zhenglong;LI Yongdi;WANG Dongxiang;CHEN Youli;GAO Qiong;DONG Qiang;Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Guizhou Medical University;Department of Stomatology, The Second Affiliated Hospital of Guiyang Traditional Chinese Medicine College;Department of Oral and Maxillofacial Surgery, Guizhou Provincial People's Hospital;

摘要(Abstract):

目的:探讨下颌升支截骨术对正畸牙移动速度的影响及机制。方法:48只建立下颌第一磨牙近中移动正畸模型新西兰大耳家兔均分为实验组和对照组,实验组家兔正畸牙同侧实施下颌骨升支截骨术,对照组不实施截骨手术,术后第1天以80 g正畸力近中移动正畸牙;在加载正畸力第5、7、14及21天时测量两组家兔正畸牙移动距离和速度,观察正畸牙的牙周组织形态学改变、成骨细胞和破骨细胞数量变化, ELISA法检测两组家兔血清中的碱性磷酸酶和Ⅰ型胶原羧基末端肽水平。结果:从正畸牵引第5天开始,实验组家兔下颌第一磨牙近中移动速度大于对照组;第5、14及21天时,实验组家兔正畸牙张力侧成骨细胞数量多于对照组、实验组家兔正畸牙压力侧破骨细胞数量多于对照组;正畸后实验组家兔血清中的碱性磷酸酶和Ⅰ型胶原羧基末端肽水平在各个时间点上均高于对照组。结论:下颌升支截骨术术后可加速正畸牙移动,并通过早期激活牙周组织中的破骨和成骨活性,加速骨的分解和合成代谢,从而加速正畸牙移动。
Objective: To investigate the effects of mandibular ramus osteotomy on speed of orthodontic tooth movement and its mechanism. Methods: A rabbit orthodontic model for mesial movement of the first mandibular molar was established based on 48 rabbits. The experimental group underwent lateral mandibular ramus osteotomy; while no surgery was performed on the control group. The 1 st day after operation, the orthodontic tooth was moved in the proximal direction of 80 g of orthodontic force. The distance and speed of orthodontic tooth movement in two groups of rabbits were measured on the 5 th, 7 th, 14 th and 21 st day after loading orthodontic force. Morphological changes in orthodontic periodontal tissues and changes in osteoblast and osteoclast numbers were observed. Changes in serum alkaline phosphatase and C-telopeptide of type I collagen were measured by ELISA. Results: From day 5 of orthodontic traction, the mesial movement of the first mandibular molar in the experimental group was faster than that in the control group. On the 5 th, 14 th and 21 st day, the number of osteoblasts on the tension side of orthodontic teeth in the experimental group was more than that in the control group.On the 5 th, 7 th and 14 th day, the number of osteoclasts on the orthodontic pressure side in the experimental group was more than that in the control group. After orthodontic treatment, serum alkaline phosphatase and C-telopeptide of type I collagen levels were higher in the experimental group than those in control group at all-time points. Conclusion: Mandibular ramus osteotomy can accelerate orthodontic tooth movement, and through the early activation of osteoclast and osteogenic activity in periodontal tissue, the decomposition and synthesis and metabolism of bone can be accelerated, thereby accelerating orthodontic tooth movement.

关键词(KeyWords): 成骨细胞;破骨细胞;正畸;下颌升支截骨术;手术优先方法;碱性磷酸酶;Ⅰ型胶原羧基末端肽
osteoblasts;osteoclasts;orthodontics;mandibular ramus osteotomy;priority method of operation;alkaline phosphatase;C-telopeptide of type I collagen

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81460101)

作者(Author): 谭俭琴;唐正龙;李永頔;王冬香;陈友利;高琼;董强;
TAN Jianqin;TANG Zhenglong;LI Yongdi;WANG Dongxiang;CHEN Youli;GAO Qiong;DONG Qiang;Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Guizhou Medical University;Department of Stomatology, The Second Affiliated Hospital of Guiyang Traditional Chinese Medicine College;Department of Oral and Maxillofacial Surgery, Guizhou Provincial People's Hospital;

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DOI: 10.19367/j.cnki.1000-2707.2019.06.006

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