贵州医科大学学报

2015, v.40;No.174(03) 237-240

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可吸收防粘连液对大鼠实验性腹壁粘连的抑制作用
Inhibitory Effect of Absorbable Anti-adhesion Fluid on Experimental Abdominal Adhesions in Rats

付凌云;刘小红;文波;肖可;徐旖旎;沈祥春;
FU Lingyun;LIU Xiaohong;WEN Bo;XIAO Ke;XU Yini;SHEN Xiangchun;Key Laboratory of Optimal Utilization of Natural Medicine Resources,Guiyang Medical College;Department of Pharmacology of Traditional Chinese Medicine,Guiyang Medical College;Guizhou Jinjiu Biological Technology Limited Company;

摘要(Abstract):

目的:观察可吸收防粘连液对大鼠实验性腹壁粘连的抑制作用。方法:60只SD大鼠随机分为生理盐水组(A组)、医用透明质酸钠凝胶组(B组)、可吸收防粘连液组(C组)3组,每组20只,制作大鼠腹壁缺损/盲肠刮伤模型,在造模后第7和第14天处死大鼠,观察粘连分级积分、解剖学、病理组织学改变。结果:可吸收防粘连液显著抑制大鼠实验性腹壁粘连,降低粘连分级积分;减少炎细胞浸润和炎性肉芽组织增生,浆膜层组织变性较轻。结论:可吸收防粘连液在一定程度抑制术后粘连。
Objective: To investigate the inhibitory effect of absorbable anti-adhesion fluid on experimental abdominal adhesion in rats. Methods: Sixty SD rats were randomly divided into 3 groups as following: normal saline group( group A),medical sodium hyaluronate gel group( group B),and absorbable anti-adhesion fluid group( group C). The abdominal wall defect and cecal abrasion model was establiehsed. After 7 d and 14 d of operation,the rats were sacrificed and the following indexes including adhesion classification, gross anatomy observation, and histopathologic examination were checked. Results: The adhesion classification was significant decreased in group C,there were significant differences compared to group A( P < 0. 05). Histopathological examination confirmed that absorbable anti-adhesion fluid could attenuate inflammatory cell infiltration,granulation tissue proliferation,and serosal tissue degeneration. Conclusions: Absorbable anti-adhesion fluid can inhibit adhesion after operation.

关键词(KeyWords): 可吸收防粘连液;大鼠,Sprague-Dawley;模型,动物;粘连;腹壁;病理学
absorbable anti-adhesion fluid;rat,Sprague-Dawley;model,animal;adhesions;abdominal wall;pathology

Abstract:

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基金项目(Foundation): 贵州省工业攻关计划[黔科合GY字(2010)3063号]

作者(Author): 付凌云;刘小红;文波;肖可;徐旖旎;沈祥春;
FU Lingyun;LIU Xiaohong;WEN Bo;XIAO Ke;XU Yini;SHEN Xiangchun;Key Laboratory of Optimal Utilization of Natural Medicine Resources,Guiyang Medical College;Department of Pharmacology of Traditional Chinese Medicine,Guiyang Medical College;Guizhou Jinjiu Biological Technology Limited Company;

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DOI: 10.19367/j.cnki.1000-2707.2015.03.007

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