贵州医科大学学报

2018, v.43;No.218(11) 1311-1314

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初诊白细胞计数与儿童高白细胞急性淋巴细胞白血病预后的关系
The Relationship between Initial Leukocyte Count and Prognosis of Pediatric with Hyperleukocytic Acute lymphoblastic Leukemia

杨小燕;金皎;黄璟;许键炜;吴西军;吴昌学;吴莎莎;马健娟;李燕;庹媛媛;杨红兰;潘海新;何志旭;胡绍燕;
YANG Xiaoyan;JIN Jiao;HUANG Jing;XU Jianwei;WU Xijun;WU Changxue;WU Shasha;MA Jianjuan;LI Yan;TUO Yuanyuan;YANG Honglan;PAN Haixin;HE Zhixu;HU Shaoyan;Department of Pediatrics,The Affiliated Hospital of Guizhou Medcial University;Tissue Engineering and Stem Cell Research Center,Guizhou Medcial University;The Key Laboratory of Molecular Biology,Guizhou Medcial University;The Key Laboratory of Endemic and Ethnic Disease,Guizhou Medcial University;Children's Hospital of Soochow University;

摘要(Abstract):

目的:研究初诊外周血白细胞(WBC)计数与儿童高白细胞急性淋巴细胞白血病(HALL)预后的关系。方法:HALL患儿121例,按照WBC计数分为WBC≥300×109/L组和<300×109/L组,比较两组患儿的总生存率、无事件生存率及复发率。结果:初诊时WBC≥300×109/L组HALL患儿无事件生存率低于WBC <300×109/L组(P=0. 034),复发率高于WBC <300×109/L组(P=0. 026),但两组总生存率比较,差异无统计学意义(P=0. 147)。结论:初诊时外周血WBC≥300×109/L的HALL患儿无事件生存率低、复发率高。
Objective: To study the relationship between initial white blood cell(WBC) count and the prognosis of pediatric with hyperleukocytic acute lymphocytic leukemia(HALL). Methods: 121 children with HALL were divided into two groups: the group with WBC≥300 × 109/L and the group with WBC < 300 × 109/L according to the initial diagnosis. The data of the patients were retrospectively analyzed. SPSS 18. 0 was employed to detect the overall survival rate(OS),events free survival(EFS) and relapse rates. Results: The estimated 5-year EFS was lower and the elapse rate was higher in the group with WBC≥300 × 109/L than those in the group with WBC < 300 × 109/L(P = 0. 034 and P = 0. 026 retrospectively). But no difference was found in OS between the two groups. Conclusions: The initial WBC count over 300 × 109/L is significantly associated with lower EFS rates and higher relapse rates.

关键词(KeyWords): 儿童;白血病,淋巴样;高白细胞;白细胞计数;无事件生存率;复发率
children;leukemia,lymphocytic;high leukocyte;white blood cell count;event free survival;relapse rate

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅联合基金[黔科合LH(2016)7240号];; 贵州省科技计划项目[黔科合LG字(2012)009号];; 贵州医科大学附院博士基金

作者(Author): 杨小燕;金皎;黄璟;许键炜;吴西军;吴昌学;吴莎莎;马健娟;李燕;庹媛媛;杨红兰;潘海新;何志旭;胡绍燕;
YANG Xiaoyan;JIN Jiao;HUANG Jing;XU Jianwei;WU Xijun;WU Changxue;WU Shasha;MA Jianjuan;LI Yan;TUO Yuanyuan;YANG Honglan;PAN Haixin;HE Zhixu;HU Shaoyan;Department of Pediatrics,The Affiliated Hospital of Guizhou Medcial University;Tissue Engineering and Stem Cell Research Center,Guizhou Medcial University;The Key Laboratory of Molecular Biology,Guizhou Medcial University;The Key Laboratory of Endemic and Ethnic Disease,Guizhou Medcial University;Children's Hospital of Soochow University;

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DOI: 10.19367/j.cnki.1000-2707.2018.11.014

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