杨小燕,金皎,黄璟,许键炜,吴西军,吴昌学,吴莎莎,马健娟,李燕,庹媛媛,杨红兰,潘海新,何志旭,胡绍燕
YANG Xiaoyan,JIN Jiao,HUANG Jing,XU Jianwei,WU Xijun,WU Changxue,WU Shasha,MA Jianjuan,LI Yan,TUO Yuanyuan,YANG Honglan,PAN Haixin,HE Zhixu,HU Shaoyan

• 1:贵州医科大学附院儿科
• 2:贵州医科大学干细胞与组织工程实验中心
• 3:贵州医科大学分子生物学重点实验室
• 4:贵州医科大学地方病与少数民族性疾病教育部重点实验室

摘要(Abstract)：

目的:研究初诊外周血白细胞(WBC)计数与儿童高白细胞急性淋巴细胞白血病(HALL)预后的关系。方法:HALL患儿121例,按照WBC计数分为WBC≥300×109/L组和<300×109/L组,比较两组患儿的总生存率、无事件生存率及复发率。结果:初诊时WBC≥300×109/L组HALL患儿无事件生存率低于WBC <300×109/L组(P=0. 034),复发率高于WBC <300×109/L组(P=0. 026),但两组总生存率比较,差异无统计学意义(P=0. 147)。结论:初诊时外周血WBC≥300×109/L的HALL患儿无事件生存率低、复发率高。
Objective: To study the relationship between initial white blood cell(WBC) count and the prognosis of pediatric with hyperleukocytic acute lymphocytic leukemia(HALL). Methods: 121 children with HALL were divided into two groups: the group with WBC≥300 × 109/L and the group with WBC < 300 × 109/L according to the initial diagnosis. The data of the patients were retrospectively analyzed. SPSS 18. 0 was employed to detect the overall survival rate(OS),events free survival(EFS) and relapse rates. Results: The estimated 5-year EFS was lower and the elapse rate was higher in the group with WBC≥300 × 109/L than those in the group with WBC < 300 × 109/L(P = 0. 034 and P = 0. 026 retrospectively). But no difference was found in OS between the two groups. Conclusions: The initial WBC count over 300 × 109/L is significantly associated with lower EFS rates and higher relapse rates.

关键词(KeyWords)： 儿童;白血病,淋巴样;高白细胞;白细胞计数;无事件生存率;复发率
children;leukemia,lymphocytic;high leukocyte;white blood cell count;event free survival;relapse rate

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅联合基金[黔科合LH(2016)7240号];; 贵州省科技计划项目[黔科合LG字(2012)009号];; 贵州医科大学附院博士基金

作者(Author): 杨小燕,金皎,黄璟,许键炜,吴西军,吴昌学,吴莎莎,马健娟,李燕,庹媛媛,杨红兰,潘海新,何志旭,胡绍燕
YANG Xiaoyan,JIN Jiao,HUANG Jing,XU Jianwei,WU Xijun,WU Changxue,WU Shasha,MA Jianjuan,LI Yan,TUO Yuanyuan,YANG Honglan,PAN Haixin,HE Zhixu,HU Shaoyan

DOI: 10.19367/j.cnki.1000-2707.2018.11.014

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