王琳琳,李志鹏,郝秀轻,程锦绣,左路广,刘华,刘圣君
WANG Linlin,LI Zhipeng,Hao Xiuqing,CHENG Jinxiu,ZUO Luguang,LIU Hua,LIU Shengjun

• 1:河北北方学院附属第一医院
• 2:河北北方学院

摘要(Abstract)：

目的:探讨丹参多酚酸盐联合百令胶囊对老年糖尿病肾病(DN)患者肾功能及血管内皮功能的影响。方法:70例老年DN患者随机分为观察组和对照组,对照组患者在给予控制血糖、血压等基础治疗同时静脉滴注丹参多酚酸盐200 mg/次(1次/d,2周为一疗程,每月1疗程,治疗3疗程),观察组在对照组基础上加服百令胶囊2.5g/次(3次/d,口服3月)于治疗前和治疗3月时采集清晨空腹静脉血及留取尿液标本,测定血清血肌酐(Scr)、血尿素氮(BUN)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、内皮素-1(ET-1)、可溶性细胞间黏附分子-1(s ICAM-1)及6-酮-前列腺素F1-α(6-Keto-PGF-1α)水平,测定尿微量蛋白(m ALB)并计算尿蛋白排泄率(UAER)。结果:治疗前,两组患者血Scr、BUN、TC、TG、HDLC、LDL-C、ET-1、s ICAM-1、6-Keto-PGF-1α、m ALB及UAER比较,差异无统计学意义(P>0.05);治疗3月时,观察组Scr、BUN、TC、TG、LDL-C、m ALB、UAER、ET-1、s ICAM-1低于对照组,HDL-C、6-Keto-PGF-1α高于对照组(P<0.05)。结论:丹参多酚酸盐联合百令胶囊治疗老年DN效果优于丹参多酚酸治疗,可有效降低DN患者炎症反应,保护肾血管内皮功能。
Objective: To explore the effect of salvianolate combined with Bailing capsule on the renal function and vascular endothelial function in elder patients with diabetic nephropathy( DN).Methods: 70 elder patients with DN were randomly divided into observation group and control group.The patients in the control group were treated with basic treatment of blood sugar,blood pressure control,and intravenous injection of salvianolate with 200 mg/time(1 time/d,1 course a month. 2-week treatment as one course,a total of 3 months). Patients in the observation group were given Bailing capsule 2. 5 g/time(3 times/d for 3 months). The morning fasting venous blood and urine specimens before and 3 months after treatment were collected. Scr,BUN,serum lipid( TC,TG,HDL-C,and LDL-C),ET-1,s ICAM-1,6-Keto-PGF-1α,and m ALB were detected. UAER was calculated. Results: Scr,BUN,TC,TG,HDL-C,LDL-C,ET-1,s ICAM-1,6-Keto-PGF-1α,and m ALB were compared with UAER,differences were not statistically significant( P < 0. 05). Three months after treatment,Scr,BUN,TC,TG,LDL-C,m ALB,UAER,ET-1,s ICAM-1 of observation group were lower than control group,HDL-C and 6-Keto-PGF-1αwere higher than control group( P < 0. 05),while 6-Keto-PGF-1α was significantly higher than that in the control group( P < 0. 05). Conclusions: Salvianolate combined with Bailing capsule can effectively reduce the inflammatory reaction in patients with DN,and protect the renal vascular endothelial function in order to better improve the renal function.

关键词(KeyWords)： 丹参多酚酸盐;百令胶囊;老年;糖尿病肾病;肾功能;血管内皮功能
salvianolate;Bailing capsule;elderly;diabetic nephropathy;renal function;vascular endothelial function

Abstract:

Keywords:

基金项目(Foundation): 河北省张家口市2016年度科研与发展指导计划基金资助项目(1621038D)

作者(Author): 王琳琳,李志鹏,郝秀轻,程锦绣,左路广,刘华,刘圣君
WANG Linlin,LI Zhipeng,Hao Xiuqing,CHENG Jinxiu,ZUO Luguang,LIU Hua,LIU Shengjun

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