邹金才
ZOU Jincai

• 1:南方医科大学附属深圳龙华新区人民医院麻醉科

摘要(Abstract)：

目的:探讨顺产妇脐带血中抗氧化剂水平与分娩疼痛的相关性。方法:88例未应用镇痛药物的自然分娩顺产妇,产后以WHO疼痛程度分3组,1级组11例、2级组53例、3级组24例,采用视觉模拟评分法(VAS)评估3个产程的疼痛程度,采集脐血进行抗氧化剂还原型谷胱甘肽(GSH)、NO、血浆β-胡萝卜素(β-Car)、VitC、VitE的检测,分析WHO疼痛程度分级、VAS评分与抗氧化剂水平的相关性。结果:各组脐血中NO水平随着疼痛等级的增加而显著增加(P<0.05),GSH、β-Car、VitC和VitE的表达水平显著降低(P<0.05);各组产妇的3个产程VAS评分差异有统计学意义(P<0.05);各组中产妇NO水平与WHO疼痛分级及产程VAS评分呈正相关(P<0.05),GSH、β-Car、VitC和VitE水平与WHO疼痛分级及产程VAS评分呈负相关(P<0.05)。结论:顺产产妇脐带血中抗氧化剂NO、GSH、β-Car、VitC和VitE水平与分娩疼痛程度有相关性。
Objective: To explore the correlation between labor pain and antioxidant levels in umbilical cord blood of pregnant women with natural labor. Methods: Eighty-eight pregnant women with natural labor without applying analgesic drugs were chosen,and divided into three groups according to WHO pain degree,11 cases in level 1 group,53 cases in level 2 group,24 cases in level 3 group. The pain degree in three labor stages was assessed with visual analog scale( VAS),cord blood was collected and the levels of glutathione( GSH),NO,beta carotene( β-Car),VitC,VitE were detected. Correlation between antioxidant levels and VAS score,WHO pain degree were analyzed. Results: NO level was increased with the increase of pain degree in the three groups( P < 0. 05),while the levels of GSH,β-Car,VitC,VitE were significantly decreased( P < 0. 05). VAS scores in three labor stages of the pregnant women in the three groups were significantly different( P < 0. 05). NO were negatively correlated VAS score and WHO pain degree( P < 0. 05),while levels of GSH,β-Car,VitC and VitE were positively correlated with VAS score and WHO pain degree( P < 0. 05). Conclusions: The labor pain degree is correlated with the levels of GSH,β-Car,VitC,VitE in umbilical cord blood of pregnant women with natural labor.

关键词(KeyWords)： 抗氧化剂;正常分娩;疼痛;谷胱甘肽;β肽萝卜素;一氧化氮;维生素类
antioxidants;natural childbirth;pain;glutathione;beta carotene;nitric oxide;vitamins

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 邹金才
ZOU Jincai

DOI: 10.19367/j.cnki.1000-2707.2014.02.023

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