9-[2-(膦酰基甲氧基)乙基]腺嘌呤的合成工艺研究
胡伦香,张建,罗春,傅晓钟
摘要(Abstract)：
关键词(KeyWords)：
肝炎,乙型;腺嘌呤;阿德福韦;药物合成
基金项目(Foundation):
作者(Author):
胡伦香,张建,罗春,傅晓钟
DOI: 10.19367/j.cnki.1000-2707.2008.05.041
参考文献(References)：
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- [3]Sekiya K,Takashima H,Ueda N.2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine Bis(2,2,2-triflu-oroethyl)Esters as Novel HBV-Specific Antiviral Rea-gents[J].Med Chem,2002(14):3138-3142.
- [4]Holy A,Gunter J,Dvorakova H,et al.Structure-Antivi-ral Activity Relationship in the Series of Pyrimidine and Purine N-[2-(2-Phosphonomethoxy)ethyl]Nucleotide Analogues.1.Derivatives Substituted at the Carbon At-oms of the Base[J].J Med Chem,1999(12):2064-2086.
- [5]Wei Chen,Michael T,Flavin,et al.An improved syn-thesis of9-[2-(diethoxyphosphonomethoxy)ethyl]adenine and its analogues with other purine bases utilizing the mit-sunobu reaction[J].Nucleosides,Nucleotides and Nu-cleic Acids,1996(15):1771-1778.
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