贵州医科大学学报

2018, v.43;No.209(02) 130-134

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通阳刮痧疗法联合中药外敷对颈型颈椎病家兔颈椎曲度及血清TNF-α的影响
Experiment of Tongyang Scrapping Therapy Combined with External Application of Traditional Chinese Medicine on Cervical Spondylotic Rabbits

黄少炎;罗先意;史红美;王光义;吕明庄;
HUANG Shaoyan;LUO Xianyi;SHI Hongmei;WANG Guangyi;LV Mingzhuang;Guizhou Medical University;Department of Acupuncture and Moxibustion,Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:探讨通阳刮痧疗法联合中药外敷对颈型颈椎病家兔的治疗效果。方法:将24只家兔随机均分为正常组、模型组和治疗组,模型组和治疗组家兔采用无创颈型颈椎病动物模型制备方法制作颈型颈椎病动物模型,造模完成后对治疗组家兔进行通阳刮痧联合中药外敷治疗27 d;3组家兔于造模前、造模和治疗结束时3个时点拍摄颈椎X线侧位片,观察颈椎生理曲度、椎间孔、椎间隙、椎体前后缘及椎体上下关节突骨质增生情况,并进行影像前评分;于造模及治疗结束时检测血清肿瘤坏死因子-α含量(TNF-α)。结果:造模结束时,模型组、治疗组颈椎生理曲度变直,椎间隙变窄,椎体边缘有轻微骨质増生,影像学评分、血清TNF-α的含量均高于正常组,差异有统计学意义(P<0.05);治疗结束时,治疗组颈椎生理曲度、椎间隙稍有恢复,椎体边缘轻微骨质増生减轻,影像学评分、血清中TNF-α的含量均低于模型组,差异有统计学意义(P<0.05)。结论:通阳刮痧疗法联合中药外敷对颈椎病家兔有积极的治疗作用,可改善颈椎X线影像学表现,其机制可能与降低TNF-α含量有关。
Objective:To observe the therapeutic effect of Tongyang Scraping therapy combined with external application of traditional Chinese medicine on cervical spondylotic rabbits.Methods:24 rabbits were randomly divided into normal group,model group and treatment group.The animal model of cervical spondylosis was made in the model group and the treatment group.After the completion of the model,the rabbits in the treatment group were treated with Tong Yang scraping and external application of traditional Chinese medicine for 27 days.In the 3 groups of rabbits,the X-ray lateral films of the cervical spine were taken by 3 time nodes at the end of the model and treatment,and the physiological curvature of cervical spine,intervertebral foramen,intervertebral space,anterior and posterior edge of vertebral body,osteogenesis of upper and lower articular process of vertebral body were observed and evaluated.Blood samples were collected at two time nodes at the end of the model and treatment,and the content of TNF-α in serum was detected.Results:At the end of the mold,in model and treatment groups the cervical physiological curvature was straightened; the intervertebral space was narrowed; the edge of the vertebral body was slightly increased; imaging score and the content of tumor necrosis factor-α in serum were higher than that in normal group,and the difference was statistically significant(P <0.05).At the end of the treatment,the physiological curvature of the cervical vertebrae and the intervertebral space slightly recovered,and slight bone growth at the edge of the vertebral body was slightly alleviated in the treatment group.The imaging score and the content of tumor necrosis factor-α in serum were lower than that in model group,and the difference was statistically significant(P < 0.05).Conclusion:Tongyang scrapping therapy combined with external application of traditional Chinese medicine has a positive therapeutic effect on cervical spondylopathy rabbits.The X-ray findings of cervical spine can be improved,and the mechanism may be related to the reduction of tumor necrosis factor-α content.

关键词(KeyWords): 颈型颈椎病;通阳刮痧疗法;中药外敷疗法;肿瘤坏死因子-α;兔;X线
cervical spondylosis;Tongyang scrapping therapy;external applications,TCD;tumor necrosis factor-α;rabbit;X-ray

Abstract:

Keywords:

基金项目(Foundation): 国家中医药管理局全国名老中医药专家传承工作室建设项目(2014);; 贵州省中医药管理局中医药、民族医药科学技术研究课题(QZYY-2016-075)

作者(Author): 黄少炎;罗先意;史红美;王光义;吕明庄;
HUANG Shaoyan;LUO Xianyi;SHI Hongmei;WANG Guangyi;LV Mingzhuang;Guizhou Medical University;Department of Acupuncture and Moxibustion,Affiliated Hospital of Guizhou Medical University;

Email:

DOI: 10.19367/j.cnki.1000-2707.2018.02.002

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