郝亚楠,黄卫
HAO Yanan,HUANG Wei

• 1:上海市第七人民医院耳鼻咽喉科

摘要(Abstract)：

目的 观察散风通窍滴丸治疗急性鼻窦炎的疗效。方法 将120例急性鼻窦炎患者均分为试验组和对照组，两组均给予头孢克肟分散片治疗，试验组加用散风通窍滴丸，治疗15 d；比较两组一般情况、临床疗效（总有效率）、治疗前后静脉血中免疫球蛋白G(IgG)、IgA、IgM、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、IL-8以及IL-10水平，鼻内镜检查Lund-Kennedy评分及症状积分，观察两组治疗期间不良反应发生情况。结果 两组患者年龄、病程、BMI、性别以及急性鼻窦炎病情比较，差异无统计学意义（P> 0.05）；治疗后，试验组总有效率（96.67%）高于对照组（75.00%）(P<0.05)，两组静脉血IgG、IgA、IgM均较治疗前升高，试验组治疗后静脉血IgG、IgA、IgM均高于对照组（P<0.05）；两组治疗后静脉血TNF-α、IL-6、IL-8、IL-10、Lund-Kennedy评分以及中医症候积分均较治疗前下降，试验组治疗后TNF-α、IL-6、IL-8、IL-10、Lund-Kennedy评分、主症积分、次症积分及总分均低于对照组（P<0.05）；两组治疗期间均未发生不良反应。结论 在抗生素基础上联合散风通窍滴丸治疗急性鼻窦炎疗效明显、安全有效。
Objective To analyze the effect of Sanfengtongqiao dropping pills in the treatment of acute sinusitis.Methods All the 120 patients with acute sinusitis were divided into test and control groups, and both groups were given cefixime disperse tablets. The test group was treated with Sanfengtongqiao dropping pills for 15 days. The general profile, clinical efficacy(total response rate),immunoglobulin G(IgG), IgA, IgM, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), IL-8,and IL-10 levels, Lund-Kennedy score by nasal endoscopy and symptom score in venous blood before and after treatment were compared. The occurrence of adverse reactions during treatment in both groups was observed.Results Age, disease duration, BMI, gender, and acute sinusitis conditions were compared in the two groups, and there was no significant difference(P> 0. 05). After treatment, the total response rate(96. 67%) was higher than the control group(75. 00%)(P<0. 05). IgG, IgA,and IgM were higher compared with those before treatment, and IgG, IgA, and IgM were higher in the test group than in the control group(P< 0. 05). Both treated venous blood TNF-α,IL-6, IL-8, IL-10, and Lund-Kennedy scores and TCM syndrome scores decreased before treatment.TNF-α, IL-6, IL-8, IL-10, Lund-Kennedy scores, primary score, secondary score, and total score in test group after treatment were lower than those of the control group(P< 0. 05). No adverse effects occurred during the treatment period in both groups.Conclusion On the basis of antibiotics combined with sanfeng tongqiao dropping pills is safe and effective in the treatment of acute sinusitis.

关键词(KeyWords)： 鼻窦炎,急性;疗效;免疫球蛋白;炎性因子;安全性;散风通窍滴丸
sinusitis,acute;efficacy;immunoglobulin;inflammatory factors;safety;sanfeng tongqiao dropping pills

Abstract:

Keywords:

基金项目(Foundation): 上海浦东新区中医薄弱学科建设项目（PDZY-2020-0401）

作者(Author): 郝亚楠,黄卫
HAO Yanan,HUANG Wei

DOI: 10.19367/j.cnki.2096-8388.2022.06.013

参考文献(References)：

• [1]MULVEY C L,KIELL E P,RIZZI M D,et al.The microbiology of complicated acute sinusitis among pediatric patients:a case series[J].Otolaryngology-Head and Neck Surgery,2019,160(4):712-719．
• [2]HANSEN M J,CARSON P J,LEEDAHL D D,et al.Failure of a best practice alert to reduce antibiotic prescribing rates for acute sinusitis across an integrated health system in the Midwest[J].Journal of Managed Care&Specialty Pharmacy,2018,24(2):154-159．
• [3]杨强，陈原邻，孙严洁，等．针刺联合鼻渊清合剂治疗急慢性鼻窦炎的效果观察[J]．医药前沿，2019,9(6):231-232．
• [4]田勇泉．耳鼻咽喉头颈外科学[M].8版．北京：人民卫生出版社，2013．
• [5]熊大经，刘蓬．中医耳鼻咽喉科学[M].3版．北京：中国中医药出版社，2012．
• [6]郑筱萸．中药新药临床研究指导原则：试行[M]．北京：中国医药科技出版社，2002．
• [7]JAIN S,CHOUDHARY K,NAGI R,et al.New evolution of cone-beam computed tomography in dentistry:combining digital technologies[J].Imaging Science in Dentistry,2019,49(3):179-190．
• [8]NEWSOME H A,POETKER D M.Odontogenic sinusitis:current concepts in diagnosis and treatment[J].Immunol Allergy Clin,2020,40(2):361-369．
• [9]KIM S W,LEE I H,KIM S W,et al.Points to consider before the insertion of maxillary implants:the otolaryngol ogist's perspective[J].Journal of Periodontal&Implant Science,2019,49(6):346．
• [10]杨志联，陈雪平，白永梅．慢性鼻窦炎患者睡眠质量现状及影响因素分析[J]．中华现代护理杂志，2020,26(20):2751-2754．
• [11]ZHAO T T,TANG H L,XIE L,et al.Scutellaria baicalensisGeorgi.(Lamiaceae):a review of its traditional uses,botany,phytochemistry,pharmacology and toxicology[J].The Journal of Pharmacy and Pharmacology,2019,71(9):1353-1369．
• [12]LEE Y M,SON E,KIM D S.Comparative study of antigouty arthritis effects of Sam-myo-whan according to extraction solvents[J].Plants,2021,10(2):278．
• [13]DENG L J,QI M,LI N,et al.Natural products and their derivatives:promising modulators of tumor immunotherapy[J].Journal of Leukocyte Biology,2020,108(2):493-508．
• [14]FU L L,CHERAYIL B J,SHI H N,et al.Modulation of food allergy by bioactive natural compounds and development of functional foods[M].Singapore:Springer Singapore,2019:147-177．
• [15]李鸿昌．对中药羌活化学成分及药理作用的研究[J]．当代医药论丛，2019,17(15):195-197．
• [16]ENG Y S,LEE C H,LEE W C,et al.Unraveling the molecular mechanism of traditional Chinese medicine:formulas against acute airway viral infections as examples[J].Molecules (Basel,Switzerland),2019,24(19):e3505．
• [17]黄剑英，朱立新，李红专．鼻窦炎口服液联合西药治疗急性鼻窦炎的临床观察[J]．湖南中医药大学学报，2017,37(4):433-435．
• [18]LO P C,LIN S K,LAI J N.Long-term use of Chinese herbal medicine therapy reduced the risk of asthma hospitalization in school-age children:a nationwide populationbased cohort study in Taiwan[J].Journal of Traditional and Complementary Medicine,2020,10(2):141-149．
• [19]杨娟．中药宣肺通窍颗粒治疗急性鼻窦炎的效果研究[J]．中国医药指南，2018,16(36):208-209．
• [20]邵亮，袁自江，王耀华，等．自拟疏风清热方雾化吸入联合阿奇霉素治疗急性鼻窦炎（肺经风热证）的疗效观察[J]．中国中医急症，2021,30 (7):1288-1290．流特征[J]．中国医学影像技术，2021,37(6):867-870．
• [13]李婉莹，蔡胜，李建初，等．超声微血管成像技术鉴别甲状腺良恶性结节应用进展[J]．中国医学影像技术，2021,37(6):949-952．
• [14]宋林科，周琦，徐鑫利．超声造影联合超声弹性成像对桥本甲状腺炎患者甲状腺结节良恶性的诊断价值[J]．陕西医学杂志，2020,49(11):1472-1475．
• [15]李文，张艳，宋青，等．甲状腺乳头状癌超声造影与肿瘤复发风险的相关性[J]．中国医学科学院学报，2021,43(3):343-349．
• [16]童瑾，黄磊，李军，等．声触诊组织量化成像联合超声造影鉴别诊断TI-RADS4类良恶性甲状腺结节[J]．中国医学影像技术，2020,36(6):828-833．
• [17]田菊，张蕾，勇强，等．常规超声联合S-Detect技术和超声造影评价甲状腺结节良恶性的价值[J]．中国超声医学杂志，2021,37(9):968-971．
• [18]吕玲，赵树樊，牛惠萍．甲状腺影像报告与数据系统分类和超声弹性成像技术及其联合诊断甲状腺结节研究进展[J]．中国医学影像技术，2021,37 (8):1238-1241．
• [19]张倩，邱爽，邓小倩，等．超声造影增强特征和定量参数鉴别甲状腺微小乳头癌的效能及与生物学行为的关系研究[J]．影像科学与光化学，2021,39(3):422-427．
• [20]曹月光，许顺，袁朝波，等．超声造影鉴别甲状腺良恶性结节的价值[J]．中国现代普通外科进展，2021,24(3):212-214．
• [21]李华梅，刘元税，景香香，等．甲状腺良恶性结节超声造影表现分析及定量模式对其诊断价值的研究[J]．中国医学装备，2018,15(7):72-75．
• [22]冯蓉，安丽，张建蕾，等．超声造影联合弹性成像对甲状腺微小乳头状癌的诊断价值研究[J]．中国肿瘤临床与康复，2020,27(12):1436-1439．
• [23]王莹，张岱，杨凡，等．超微血流显像与超声造影对甲状腺实性结节的诊断价值[J]．中国肿瘤临床，2021,48(14):711-715．
• [24]赵恒达，王怡．甲状腺良恶性结节SWE技术参数与超声造影参数的相关性及联合诊断价值分析[J]．影像科学与光化学，2021,39(4):526-532．
• [25]施燕芸，李念芬，张文，等．超声造影成像特征及定量参数对甲状腺良恶性结节的诊断价值[J]．临床和实验医学杂志，2019,18(2):201-205.

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