贵州医科大学学报

2019, v.44;No.225(06) 716-720

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2118例住院分娩孕妇乙型肝炎病毒感染血清标志物及病毒载量分析
Analysis of Serum Markers and Viral Loads of Hepatitis B Virus Infection in 2 118 Pregnant Women

唐小敏;令狐艳;张丽;赵苏晔;刘淳婷;
TANG Xiaomin;LINGHU Yan;ZHANG Li;ZHAO Shuye;LIU Chunting;Guizhou Provincial Center for Disease Control and Prevention;School of Basic Medicine, Guizhou Medical University;

摘要(Abstract):

目的:对贵州某两县孕妇乙型肝炎病毒(HBV)血清标志物及病毒载量进行检测,探讨孕妇乙型肝炎病毒对新生儿的影响。方法:选取住院分娩的孕妇2 118例,采集静脉血开展乙肝病毒表面抗原(HBsAg)筛查;对筛查HBsAg阳性孕妇采用酶联免疫吸附试验检测HBsAg和乙肝病毒e抗原(HBeAg)、荧光定量PCR法检测HBV-DNA病毒载量;清洁、去除脐带表面污染血液,酒精消毒脐带采血部位,采集脐带血进行HBsAg检测。结果:2 118例孕妇血清乙型肝炎病毒标志物检测结果显示,HBsAg阳性119例,阳性率为5.62%、HBV感染为121例,感染率为5.71%;121例HBV感染孕妇中HBV-DNA>1.0×10~(6 )IU/L的构成比为36.36%,>1.0×10~9IU/L构成比为26.45%;121例HBV感染孕产妇所生婴幼儿中,脐带血阳性率为30.58%,孕产妇HBeAg阳性和HBeAg双阳性、HBV-DNA≥1.0×10~6IU/L与新生儿脐带血HBV感染有关(P<0.05)。结论:研究地区孕妇乙型肝炎病毒感染较高,重视HBeAg阳性及HBV-DNA≥1.0×10~6IU/L孕妇的干预,减少对新生儿的影响。
Objective: To investigate the status of Hepatitis B virus serum markers and viral load infection in pregnant women in minority areas of southeastern Guizhou and to study the effects of hepatitis B virus on newborns. Methods: Randomly sampling method was adopted on 2 118 pregnant women in hospitals, and collecting venous blood for HBsAg screening. For pregnant women with HBsAg-positive, Enzyme-linked Immunosorbent Assay was used to detect the serum markers of both HBsAg and HBeAg, and Fluorescenct quantitative PCR was used to detect the viral loads of HBV-DNA. The umbilical cord blood was collected at birth after removal of contaminants and disinfected with alcohol, and umbilical cord blood was used for serological HBsAg tests. Results: The detection of serum Bepatitis B virus markers in 2118 pregnant women indicated that: the positive rate of HBsAg was 5.62% and the infection rate of HBV was 5.71%. The composition ratio of HBV-DNA greater than 1.0×10~6 IU/L in 121 pregnant women was 36.36%; the composition ratio greater than 1.0×10~9 IU/L was 26.45%. The positive rate of umbilical cord blood was 30.58% in 121 infants born to HBV infected pregnant women. Maternal HBeAg postitive and HBV-DNA≥1.0×10~6IU/L were associated with umbilical cord blood HBV infection in infants, and the difference was statistically significant(P<0.05). Conclusions: The pregnant women with Hepatitis B virus infection were relatively high in minority areas of southeastern Guizhou Province. The intervention in pregnant women with HBeAg positive and HBV-DNA ≥1.0×10~6IU/L should be strengthened to reduce the impact on newborns.

关键词(KeyWords): 乙型肝炎病毒;孕妇;血清标志物;病毒载量
hepatitis B virus;pregnancy;serum marker;viral load

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅科技计划项目[黔科合SY字(2011)3051号]

作者(Author): 唐小敏;令狐艳;张丽;赵苏晔;刘淳婷;
TANG Xiaomin;LINGHU Yan;ZHANG Li;ZHAO Shuye;LIU Chunting;Guizhou Provincial Center for Disease Control and Prevention;School of Basic Medicine, Guizhou Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2019.06.020

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