赵喜明;孙志清;苏全平;
ZHAO Ximing;SUN Zhiqing;SU Quanping;Department of Internal Medicine-Neurology, Affiliated Linyi People's Hospital of Qingdao University;Central Lab, Department of Internal Medicine-Neurology, Linyi People's Hospital;

• 1:青岛大学附属临沂市人民医院神经内科
• 2:青岛大学附属临沂市人民医院中心实验室

摘要(Abstract)：

目的:比较左乙拉西坦与卡马西平治疗儿童难治性癫痫的临床疗效及安全性。方法:将92例难治性癫痫患儿随机均分为两组,观察组给予左乙拉西片坦治疗,对照组给予卡马西平片治疗,用药6月;观察两组患儿治疗6个月时的临床疗效、癫痫发作频率,采用韦氏儿童智力量表中国修定版(WISC-CR)评价治疗前后两组患儿认知功能,ELISA检测两组患儿治疗前后血清lgA、lgM、lgG水平,并统计治疗后不良反应发生情况。结果:治疗后,观察组治疗总有效率高于对照组(P<0.05),癫痫发作频率低于对照组(P<0.05),WISC-CR各项评分均高于对照组(P<0.05),血清lgA、lgG、lgM水平高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:左乙拉西坦治疗儿童难治性癫痫效果优于卡马西平,用药安全。
Objective: To investigate the clinical efficacy and safety of Levetiracetam tablets and Carbamazepine tablets in treating children with refractory epilepsy. Methods: 92 children with refractory epilepsy were randomly divided into two groups with equal number. Observation group were treated with Levetiracetam tablets, and control group were treated with Carbamazepine tablets, both treated for 6 months. Then, observing clinical efficacy, frequency of seizures, improvement of neurocognitive function(adopting WISC-CR) before and after treatment were evaluated, ELISA assay was adopted to detect serum IgA, IgM and IgG level, and the occurrence of adverse reactions was recorded. Results: The total effective rate of the observation group was significantly higher than that of the control group(P<0.05). The frequency of seizures in the observation group was significantly lower than that of the control group(P<0.05). WISC-CR scores were higher than before and that of the control group(P>0.05). The levels of lgA, lgG and lgM in the observation group were significantly higher than those in the control group(P<0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05). Conclusion: Levetiracetam is superior to Carbamazepine in the treatment of refractory epilepsy in children.

关键词(KeyWords)： 左乙拉西坦;卡马西平;难治性癫痫;疗效;认知功能
levetiracetam;carbamazepine;refractory epilepsy;clinical efficacy;cognitive function

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81301114)

作者(Authors): 赵喜明;孙志清;苏全平;
ZHAO Ximing;SUN Zhiqing;SU Quanping;Department of Internal Medicine-Neurology, Affiliated Linyi People's Hospital of Qingdao University;Central Lab, Department of Internal Medicine-Neurology, Linyi People's Hospital;

DOI: 10.19367/j.cnki.1000-2707.2019.06.015

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