贵州医科大学学报

2017, v.42;No.203(08) 979-982

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血清PCT、CRP及LPS在输尿管上段嵌顿性结石患者术后尿道感染诊断中的价值
The Value of Serum PCT,CRP and LPS Level Determination in the Diagnosis of Postoperative Urethral Infection in Patients with Incarcerated Calculi in Upper Ureter

丁珂;滕毅;
DING Ke;TENG Yi;Clinical Laboratory of Naval Authorities Clinic;Clinical Laboratory of Kunming General Hospital of PLA;

摘要(Abstract):

目的:探讨血清降钙素原(PCT)、C-反应蛋白(CRP)及脂多糖(LPS)水平测定在输尿管上段嵌顿性结石患者术后尿道感染诊断中的应用价值。方法:抽取输尿管上段嵌顿性结石行手术治疗后并发尿道感染患者49例为观察组,另取同期术后未并发尿道感染的输尿管上段嵌顿性结石患者51例为对照组;分别于手术前及术后1 d抽取空腹静脉血,采用化学发光法检测血清PCT水平,采用酶联免疫吸附法检测血清LPS水平,采用免疫比浊法检测血清CRP水平,比较两组患者3项血清学指标的差异。结果:手术前两组患者血清PCT、CRP及LPS水平比较,差异无统计学意义(P>0.05);术后1 d观察组血清PCT、CRP及LPS均高于对照组,差异有统计学意义(P<0.05);手术前,两组PCT、CRP、LPS阳性率比较,差异无统计学意义(P>0.05),术后1 d,观察组PCT、CRP、LPS阳性率均高于对照组,差异有统计学意义(P<0.05)。结论:血清PCT、CRP、LPS水平检测可为输尿管上段嵌顿性结石术后尿道感染诊断提供重要客观依据。
Objective: To discuss the value of serum procalcitonin( PCT),C-reactive protein( CRP) and lipopolysaccharide( LPS) level determination in the diagnosis of postoperative urethral infection in patients with incarcerated calculi in upper ureter. Methods: From May 2014 to March 2017,49 cases of incarcerated calculi in upper ureter after surgical treatment of urinary tract infection patients in our hospital were selected as observation group,and 51 patients of no urinary tract infection in upper ureter at the same period were selected as a control group. Fasting venous blood was extracted before and after 1 d surgery,and the levels of serum PCT were detected by chemiluminiscence. The level of LPS was detected by the enzyme linked immunosorbent assay,and the level of CRP was detected by the immunoturbidimetry. The difference of 3 serological indicators in the two groups was compared. Results: The difference was no statistical significance in comparison of serum PCT,CRP and LPS levels between the two groups before operation( P > 0. 05). The levels of serum PCT,CRP and LPS in the observation group were higher than those in the control group 1 d after surgery( P < 0. 05).According to the comparison of positive rate of PCT,CRP and LPS in the two groups before surgery,the difference was not statistically significant( P > 0. 05). 1 d after surgery,the positive rate of PCT,CRP and LPS in the observation group was higher than that in the control group( P < 0. 05),the difference was statistically significant( P < 0. 05). Conclusion: The level detection of serum PCT,CRP and LPS can provide an important objective basis for the diagnosis of urethral infection in patients with incarcerated calculi in upper ureter,which is helpful to improve the diagnostic accuracy.

关键词(KeyWords): 输尿管结石;尿道感染;降钙素原;C-反应蛋白;脂多糖
ureteral calculi;urethral infection;procalcitonin;C-reactive protein;lipopolysaccharide

Abstract:

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作者(Author): 丁珂;滕毅;
DING Ke;TENG Yi;Clinical Laboratory of Naval Authorities Clinic;Clinical Laboratory of Kunming General Hospital of PLA;

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DOI: 10.19367/j.cnki.1000-2707.2017.08.025

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