刘大男,李金生,赵慧强
LIU Da nan; LI Jin sheng; ZHAO Hui qiang (Department of Intcrnal Medicine;

• 1:贵阳医学院附院心内科!贵州贵阳550004
• 2:贵阳医学院附院心内科!贵州贵阳550004
• 3:贵阳医学院附院心内科!贵州贵阳550004

摘要(Abstract)：

目的 :探讨冠心病 (CHD)患者血清脂质过氧化物 (LPO)、超氧化物歧化酶 (SOD)、血脂的变化及其相互关系。方法 :测定了 46例CHD患者及 37例正常人血清丙二醛 (MDA)、SOD、总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL -C)、高密度脂蛋白胆固醇 (HDL -C)水平。结果 :CHD患者MDA、TC、TG、LDL -C显著高于正常 (P <0 0 1) ,SOD、HDL -C显著低于正常 (P <0 0 2 ) ,而且MDA与TC、LDL -C呈显著正相关 (r=0 31,P <0 0 5 ;r =0 37,P <0 0 2 ) ,SOD与HDL -C呈显著正相关 (r =0 34,P <0 0 5 )。结论 :CHD患者脂质过氧化 (LP)增强与抗氧化功能降低及脂质代谢障碍之间存在一定关系
Objective: To deretmine the changes and relationships between malomdialdehyde (MDA), superoxide dismutase (SOD) and serum lipids in serum of the patients with coronary heart diseae (CHD).Methods:The leves of serum highdensity lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),total cholesterol (TC), triglyceride (TG),MDA and SOD were measured in 46 patients and 37 healthy of subjects. Results:Our data confirmed that the levels of TC,TG,LDL-C and MDA were higher (P<0 01),the levels of HDL-C and SOD were lower (P<0 02) in CHD patients than in controls.Correlation analysis revealed that the levels of TC and LDL-C correlated significantly with level of MDA (r=0.31,P<0 05;r=0.37,P<0.02),level of HDL-C correlated significantly with level of SOD (r=0.34,P<0.05).Conclusion:The results suggested that there was close relationship of serum lipids with MDA and SOD.

关键词(KeyWords)： 冠状动脉病;丙二醛;超氧化物歧化酶;血清脂质
coronary disease; malondialdehyde;superoxide dismutase;serum lipids

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 刘大男,李金生,赵慧强
LIU Da nan; LI Jin sheng; ZHAO Hui qiang (Department of Intcrnal Medicine;

DOI: 10.19367/j.cnki.1000-2707.2001.01.014

参考文献(References)：

• [1]SteingbergD ,Parthasarathys ,CarewTE ,etal.Modifi cationoflowdensitylipoproteinsthatincreaseitsatherc genicity [J].NEnglJMed ,1989,32 0 :915 - 92 4.
• [2 ]张军 ,李兰荪 .小而密LDL -冠状动脉疾病重要的危险因素 [J].心血管病学进展 ,2 0 0 0 ,2 1(4 ) :2 43- 5 .
• [3]BogerRH ,Bode -BogerSM ,FrolichJC .TheL -arginine-nitricoxidepathway :roleinatherosclerosisandtherapeuticimplications [J].Atherosclerosis,1996 ,12 7:1.
• [4 ]周永昌 ,翁心植 TXA2 -PGI2 的平衡与临床 [J] 中华内科杂志 ,1987,2 6 :49.
• [5 ]黄晨 ,崔致贤 氧自由基在冠心病研究中的现状与展望 [J] 心血管病学进展 ,1994,15 (3) :12 9.
• [6 ]王浩 ,李儒汉 .冠心病患者血液脂质过氧化物及有关酶变化的临床意义 [J] 中华心血管病杂志 ,1992 ,2 0(2 ) :10 4.
• [7]StringerMD ,GorogPG ,AzadehFreeman ,etal.Lipidper oxidesandatherosclerosis [J].BMJ,1989,2 98(4 ) :2 81.
• [8]ChenY ,ZhouM ,LiuYL ,etal.Lipoperoxidativedam ageinpatientswithcoronaryheartdisease [J].MedSciRes,1988,16 :10 5 9.
• [9]SmitT .TodaT ,KummerowFA ,etal.Plasmalipidperoxidationinhyperlipidemicchickens [J].Atherosclero sis ,1985 ,5 7:119.
• [10 ]WangJ ,LuYc ,ZhenEZ ,etal.Effectoflipidperoxi daseonprostacydimandthromboxanegenerationinhy percholesterolemicrabbits [J].ExpMedPathol,1988,48:15 3 - 7.
• [11]郭虹 ,陈在嘉 ,徐义枢 血清脂质与脂质过氧化关系的临床研究 [J] 中国循环杂志 ,1991,6 :373 - 5 .
• [12 ]陈琪 ,蔡海江 ,范乐明 ,等 .人血浆低密度脂蛋白亚组成氧化反应敏感性比较 [J].生物化学与生物物理学报 ,1994,2 6 (3) :2 71- 5 .
• [13]WortonAR ,MontgmeryME ,KentRS .Effectofhy drogenperoxideonprostaglandinproductionandcelluiarintegrityinculturedporcineaorticendathelialcells [J].JClinInvest ,1985 ,76 :2 95 .

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