贵州医科大学学报

2019, v.44;No.221(02) 235-238+248

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Micro-26a对沙格列汀治疗糖尿病伴非酒精性脂肪肝疗效的影响
The Effect of Micro-26a Expression on Saxagliptin Treatment Efficacy on Patients with Type 2 Diabetes Mellitus with Non-alcoholic Fatty Liver Disease

陈彦平;张金苹;
CHEN Yanping;ZHANG Jinping;Endocrinology Department,Mentougou District Traditional Chinese Medicine Hospital,Beijing;Endocrinology Department,China-japan Friendship Hospital;

摘要(Abstract):

目的:探究循环miRNA-26a水平对沙格列汀治疗糖尿病伴非酒精性脂肪肝(NAFLD)疗效的影响。方法:113例2型糖尿病伴NAFLD患者,采用沙格列汀治疗6个月;以患者治疗1 d时的血清miR-26a相对表达中位数为临界值,将患者分为miR-26a高表达组(n=49)及miR-26a低表达组(n=64);比较两组患者治疗前及治疗6个月时的空腹血糖(FPG)、餐后2 h血糖(2hPPG)、糖化血红蛋白(Hb A1c)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(GGT)、总胆固醇(TC)及甘油三酯(TG)水平;比较沙格列汀对两组患者NAFLD的治疗效果。结果:治疗前两组患者血清FPG、2hPPG、HBA1c、ALT、AST、GGT、TC及TG水平比较,差异无统计学意义(P> 0. 05);治疗后两组患者血清FPG、2hPPG、HBA1c、ALT、AST、GGT、TC及TG水平均较治疗前显著降低(P <0. 05),但治疗后两组患者血清FPG、2hPPG、HBA1c、ALT、AST、GGT、TC及TG水平比较,差异无统计学意义(P> 0. 05); 113例患者治疗NAFLD的总有效率为73. 5%,miR-26a高表达组治疗NAFLD的总有效率显著高于miR-26a低表达组,差异有统计学意义(P <0. 05)。结论:高miR-26a表达的糖尿病伴NAFLD患者对沙格列汀治疗的敏感性更高。
Objective: To investigate the effect of circulating miRNA-26 a on the efficacy of saxagliptin in the treatment of patients with type 2 diabetes mellitus( T2 D) complicated with non-alcoholic fatty liver disease( NAFLD). Methods: A total of 113 T2 D patients complicated with NAFLD admitted to the Mentougou district traditional Chinese medicine hospital hospital from January 2015 to December2017 were selected as the study subjects and treated with saxagliptin for 6 months. Based on the median relative expression of serum miR-26 a as a critical value,patients were divided into miR-26 a high expression group( n = 49) and low expression group( n = 64). The improvement of blood glucose,liver function and blood lipid level before/after treatment and the therapeutic effect of NAFLD were compared in the two groups. Results: The blood glucose levels in both groups had no significant difference( P > 0. 05),but the treatment remarkably decreased blood glucose levels in both groups( P < 0. 05).Interestingly,the patients with high expression of miR-26 a had more significant reduction in ALT,AST,GGT,TC and TG( P < 0. 05). The total effective rate of miR-26 a high expression group was83. 7%,while the total effective rate of low expression group was 65. 6%,the difference was statistically significant( P < 0. 05). Conclusion: Monitoring serum miR-26 a expression may provide the basis for the evaluation of the therapeutic effect of saxagliptin on T2 D patients complicated NAFLD.

关键词(KeyWords): 微小RNA;miR-26a;糖尿病;酒精性脂肪肝;肝功能;血糖;血脂
micro RNA;miR-26a;diabetes;alcoholic fatty liver disease;liver function;blood glucose;blood fat

Abstract:

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基金项目(Foundation): 北京市科学技术委员会基金资助项目(2017YKSJ04)

作者(Author): 陈彦平;张金苹;
CHEN Yanping;ZHANG Jinping;Endocrinology Department,Mentougou District Traditional Chinese Medicine Hospital,Beijing;Endocrinology Department,China-japan Friendship Hospital;

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DOI: 10.19367/j.cnki.1000-2707.2019.02.023

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