黄虎,栗娜,杨柳,王志刚,李自健,姚杰,李鸣芳,詹姗姗
HUANG Hu,LI Na,YANG Liu,WANG Zhigang,LI Zijian,YAO Jie,LI Mingfang,ZHAN Shanshan

• 1:中国人民解放军第161医院肿瘤科
• 2:武汉市卫生计生执法督察总队
• 3:湖北省肿瘤医院肿瘤科

摘要(Abstract)：

目的:探讨核转录因子-κB(NF-κB)、细胞周期素D1(Cyclin D1)及p27在非小细胞肺癌(NSCLC)组织中的表达、及与患者化疗敏感性及预后的关系。方法:采用免疫组织化学方法检测84例NSCLC病理标本中NF-κB、Cyclin D1和p27的表达水平并计算其阳性表达率,采用Spearman法分析NF-κB、Cyclin D1和p27表达水平的相关性,比较不同NF-κB、Cyclin D1和p27表达水平的NSCLC患者的近期和远期疗效;分析不同NF-κB、Cy-clin D1及p27表达水平的NSCLC患者中位OS及中位PFS,COX回归分析影响NSCLC预后的因素。结果:NSCLC组织中NF-κB的表达率为88. 1%,Cyclin D1的表达率为71. 4%,p27的表达率为32. 1%; NF-κB与Cy-clin D1的表达呈正相关(r=0. 256,P=0. 019),Cyclin D1与p27的表达呈负相关(r=-0. 730,P=0. 000),NF-κB与p27无相关关系(r=-0. 212,P=0. 053); NF-κB、Cyclin D1高表达患者的近期总有效率(CR+PR)显著低于低表达的患者,p27高表达患者显著高于低表达患者(P <0. 01); NF-κB、Cyclin D1高表达患者的中位OS及中位PFS显著低于低表达患者,p27高表达患者显著高于低表达的患者(P <0. 01); NF-κB表达、Cyclin D1表达和p27表达是NSCLC预后的影响因素。结论:检测NF-κB、Cyclin D1和p27的表达可作为NSCLC患者化疗敏感性及其预后判断的指标。
Objective: To investigate the expression of NF-κB、CyclinD1 and p27 in non-small cell lung cancer( NSCLC) and the relationship between chemosensitivity and prognosis in patients with NSCLC. Methods: The expression of NF-κB,CyclinD1 and p27 in 84 cases of NSCLC were detected by immunohistochemical method and the positive expression rate of p27 was calculated. The correlation between NF-κB,CyclinD1 and p27 expression levels was analyzed by Spearman method,and the Short-and long-term outcomes of NF-κB,CyclinD1 and p27 expression levels in patients with NSCLC were compared. Median OS and median PFS in NSCLC patients with different expression levels of NF-κB,CyclinD1 and p27 were analyzed,and prognostic factors of NSCLC were analyzed by Cox regression. Results: The expression rate of NF-κB was 88. 1%,the expression rate of CyclinD1 was 71. 4%and the expression rate of p27 was 32. 1% in NSCLC. The expression of NF-κB and CyclinD1 shown positive correlation( r = 0. 256,P = 0. 019). The expression of CyclinD1 and p27 shown negative correlation( r =-0. 730,P = 0. 000). There was no correlation between NF-κB and p27( r =-0. 212,P =0. 053). The short-term total effective rate of patients with high expression of NF-κB and CyclinD1 was significantly lower than that of patients with low expression,and patients with high expression of p27 were significantly higher than those with low expression( P < 0. 01). The median OS and median PFS in patients with high expression of NF-κB and CyclinD1 were significantly lower than those in patients with low expression,and patients with high expression of p27 were significantly higher than those with low expression( P < 0. 01). Expression of NF-κB,CyclinD1 and p27 were the prognostic factors of NSCLC. Conclusion: Detection of the expression of NF-κB,CyclinD1 and p27 may be used as an index of chemosensitivity and prognosis in NSCLC patients.

关键词(KeyWords)： 癌,非小细胞肺;核转录因子-κB;细胞周期素D1;p27;抗肿瘤联合化疗方案;预后
cancer,non-small cell lung;nuclear factor-κB;cyclinD1;p27;antitumor combined chemotherapy regimen;prognosis

Abstract:

Keywords:

基金项目(Foundation): 湖北省卫计委指导性项目(WJ2017F009);; 湖北省科技厅自然科学基金(2018CFB711);; 武汉市解放军第161医院“十三五”科研面上项目

作者(Author): 黄虎,栗娜,杨柳,王志刚,李自健,姚杰,李鸣芳,詹姗姗
HUANG Hu,LI Na,YANG Liu,WANG Zhigang,LI Zijian,YAO Jie,LI Mingfang,ZHAN Shanshan

DOI: 10.19367/j.cnki.1000-2707.2019.02.014

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