林康,罗泽宇,高原,潘益凯,李程飞,石菲,曹新生,赵疆东,胡泽兵,王永春
LIN Kang,LUO Zeyu,GAO Yuan,PAN Yikai,LI Chengfei,SHI Fei,CAO Xinsheng,ZHAO Jiangdong,HU Zebing,WANG Yongchun

• 1:空军军医大学
• 2:空军军医大学航空航天医系航空航天医学训练教研室

摘要(Abstract)：

正常的血管系统是维持内环境稳定和细胞生长代谢的基础,其功能的维持由多个内外因素共同决定,血管内皮生长因子(VEGF)、Wnt/β-catenin、Notch、促血管生成素I/II(Ang-I/II)等多个信号通路对血管发育的各个阶段产生重要影响,其中Notch信号通路作为人体内一条进化上十分保守的传导通路,在血管功能调控中起着特殊的作用。本文就近年来Notch信号通路对血管内皮细胞(VECs)和血管平滑肌细胞(SMCs)的调节作用的研究进展作一综述。

关键词(KeyWords)： Notch;信号通路;心血管;平滑肌细胞;内皮细胞;基因调控

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81741121,81471817)

作者(Author): 林康,罗泽宇,高原,潘益凯,李程飞,石菲,曹新生,赵疆东,胡泽兵,王永春
LIN Kang,LUO Zeyu,GAO Yuan,PAN Yikai,LI Chengfei,SHI Fei,CAO Xinsheng,ZHAO Jiangdong,HU Zebing,WANG Yongchun

DOI: 10.19367/j.cnki.1000-2707.2019.03.004

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