卓贤露,冯红超,宋宇峰
ZHUO Xian-lu; FENG Hong-chao; SONG Yu-feng (Department of Oral and Maxillofacial Surgery;

• 1:贵阳医学院附院口腔科
• 2:贵阳医学院附院口腔科
• 3:贵阳医学院附院口腔科 贵州贵阳550004
• 4:贵阳医学院耳鼻咽喉专业研究生

摘要(Abstract)：

目的 :观察口腔鳞癌组织中Survivin的表达 ,探讨Survivin在口腔鳞癌中的作用。方法 :收集口腔鳞癌标本 4 2例 ,其中有淋巴结转移者 14例 ,10例正常口腔黏膜组织 ,用免疫组织化学染色法探测Survivin的表达情况。结果 :正常口腔黏膜均未见Survivin表达 ,口腔鳞癌中Survivin表达阳性率为 80 95 % (34/ 4 2 ) ,Survivin表达阳性率与淋巴结转移有关 (P <0 0 5 ) ,未见与组织学分化程度、临床分期、年龄和性别相关 (P >0 0 5 )。结论 :Survivin在口腔鳞癌组织中的高度表达在口腔鳞癌发展中起重要作用 ,并与其淋巴结转移关系密切
Objective: To detect the role of survivin in oral squamous cell carcinoma through observing the expression of survivin in the carcinoma. Methods: Expression of survivin in 42 cases of oral squamous cell carcinoma (14 cases of them with lymph node metastasis) and 10 cases of normal oral mucosa were detected by immunohistochemistry. Results: Survivin was found in 34 (80.95%) cases of oral squamous cell carcinoma, and no expression of survivin in normal tissue was detected. The survivin expression was significantly associated with lymph node metastasis status (P<0.05) but not with histological grade, clinical stage of the tumor or age and sex of the patients (P>0.05). Conclusions: Overexpression of survivin may play an important role in the development of oral squamous cell carcinoma and it closely correlates with the tumor’s lymph node metastasis.

关键词(KeyWords)： 口腔肿瘤;细胞凋亡;免疫组织化学;凋亡抑制蛋白;生存素
mouth neoplasms; cell death; immunohistochemistry; inhibitor of apoptosis; survivin

Abstract:

Keywords:

基金项目(Foundation): 贵州省第二批跨世纪人才省政府专项基金 -黔科合人专字(2 0 0 0 ) 981 3号

作者(Authors): 卓贤露,冯红超,宋宇峰
ZHUO Xian-lu; FENG Hong-chao; SONG Yu-feng (Department of Oral and Maxillofacial Surgery;

DOI: 10.19367/j.cnki.1000-2707.2004.03.002

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