贵州医科大学学报

1996, (01) 23-25

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依那普利对高血压病降压疗效的临床评价
Clinical Observation of the Long-time Antihypertensive Effects of Enalapril

方颖;吴立荣;车正兰;姚淙;王定胜;马启玲;黄铁生;
Fang Ying Department of Internal Medicine,Guiyang Medical College

摘要(Abstract):

对依那普利治疗高血压病进行了降压疗效及多项指标的观察共3年,降压效果与治疗前相比差异显著(P<0.001),治疗后血甘油三酯和胆固醇水平显著下降并低于双氢克尿塞组(P<0.01~0.001)。而心率、血糖、血胰岛素、血钠及肌酐、尿酸、左室重量指数、血白细胞总数、尿蛋白等两组治疗前、后均无明显改变(P>0.05)。
The long-time antihypertensive effects of enalapril were observed and compared with that of hy- drochlorothiazide in 30 patients with essential hypertension for three years.The significant antihy- pertensive effects were observed in both of the drugs(P<0.001).The heart rates,serum glucose, insulin,sodium,creatinine,uric acid,left ventricular mass index(LVMI),white blood cell counts, and urinary proteins had no significant changes after the treatments(P>0.05).Serum potassium and chlorine in the group of hydrochlorothiazide significantly lowered after the treatment compared with that in the group of enalapril(P<0.01~0.001).Serum triglyceride and cholesterol in the group of enalapril significantly lowered apfter the treatment compared with that in the group of hy- drochlorothiazide(P<0.01~0.001).In several patients,cough was observed in the group of enalapril.

关键词(KeyWords): 依那普利;双氢克尿塞;高血压
enalapril;hydrochlorothiazide;hypertension

Abstract:

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作者(Author): 方颖;吴立荣;车正兰;姚淙;王定胜;马启玲;黄铁生;
Fang Ying Department of Internal Medicine,Guiyang Medical College

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DOI: 10.19367/j.cnki.1000-2707.1996.01.011

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