徐胜生,焦俊,曾曦,张兰花
XU Sheng-sheng; JIAO Jun; ZENG Xi; ZHANG Lan-hua (Department of Radiology;

• 1:贵阳医学院附院放射科
• 2:贵阳医学院附院放射科
• 3:贵阳医学院附院放射科
• 4:贵阳医学院附院放射科 贵州贵阳550004

摘要(Abstract)：

目的 :探讨结肠运动与胃动素 (MTL)、血管活性肠肽 (VIP)、P物质 (SP)的关系。方法 :运用结肠运输实验观察正常人结肠运输情况 ,采用放射免疫测定餐前后血中MTL ,VIP及SP的浓度。结果 :(1)青、中、老年组结肠运动力由强减弱 ,青、中年组 4 8h内结肠运动力明显高于老年组 (P <0 0 5 )。男女组间结肠运输试验差异无显著性 (P >0 0 5 ) ;(2 )空腹MTL ,VIP ,SP的浓度 :(2 6 7 34± 10 9 5 8)ng/L ,(176 93± 12 6 6 4 )ng/L ,(2 6 19± 19 12 )ng/L。餐后血MTL ,VIP ,SP分别为 :(2 88 0 8± 12 7 83)ng/L ,(15 2 14± 90 72 )ng/L ,(36 86± 19 0 8)ng/L ;(3)餐后 1h各组血中MTL ,SP ,VIP浓度 :青年组分别为 :(2 4 9 14± 10 4 4 7)ng/L ,(12 5 0 5± 79 97)ng/L ,(36 6 7± 2 0 92 )ng/L。中年组分别为 :(2 6 5 6 4± 12 5 5 2 )ng/L ,(14 3 38± 92 84 )ng/L ,(38 5 2± 2 2 2 6 )ng/L。老年组分别为 :(377 84±12 3 6 9)ng/L ,(2 0 4 77± 83 76 )ng/L ,(34 73± 10 30 )ng/L。老年组MTL ,VIP与青中年组比较 ,差异有显著性 (P <0 0 5 )。SP各组间无显著性差异 (P >0 0 5 )。男女组间差异无显著性 (P >0 0 5 ) ;(4)空腹与餐后比较 :青、中、老年组餐后SP均明显高于餐前 (P <0 0 5 )
Objective: To study the relationship of colonic transit with motilin (MTL), vasoactive intestinal polypeptide (VIP), and substance P (SP).Methords: 90 healthy adults (52 males, 39 femals), were divided into three groups: young group (YG, 34 cases, 20-39-years old), middle-aged group (MG, 33cases, 40-59-years old), and old group (OG, 26 cases beyond 60). Colon transit of each group was observed by colonic transit test, Plasma MTL, VI, SP concentrations were observed using radioimmunoassy (RIA).Results: 1) Colon motility of YG and MG groups was significantly stronger than that of OG within 48 hours (P<0.05) . The order of colon motility from strong to weak was YG, MG, and OG. There was no significant difference of colon motility between males and females (P>0.05). 2) Plasma MTL and VIP of OG were significantly higher than those of YG and MG (P<0.05) , There was no significant differences among three groups about plasma SP level (P>0.05). 3) ; Plasma SP levels of three groups after meal were significantly higher than those before meal (P<0.05) ; Plasma MTL was somewhat higher and plasma VIP was somewhat lower after meal (P>0.05). 4) Plasma MTL, VIP levels increased progressively, and SP decreased progressively within 72 hours after meal showing in intervals of 24 hours.Conclusions: 1) The results of colon transit within 72 hours conform to 80%TT standards. 2) Plasma MTL VIP SP concentrations of healthy adults before meal are (267.34±109.58)ng/L,(176.93±126.64)ng/L,(26.19±19.12)ng/L, and after meal are (288.08±127.83)ng/L,(152.14±90.72)ng/L,(36.86±19.08)ng/L respectively. 3) Plasma MTL VIP levels before and after meal are increasingly higher as age increasing. 4) Plasma MTL level increase somewhat, plasma SP level significantly increase and plasma VIP level somewhat decrease after meal. 5) When colon motility progressively decrease, plasma MTL VIP levels progressively increase, but plasma SP level progressively decrease.

关键词(KeyWords)： 结肠;血管活性肠肽;P物质;放射免疫测定;结肠运输实验
colon; vasoactive intestinal peptide; substance P; radioimmunoassay; colon transit test

Abstract:

Keywords:

基金项目(Foundation): 贵阳市科技局资金资助 ( 2 0 0 2 0 1 3)

作者(Authors): 徐胜生,焦俊,曾曦,张兰花
XU Sheng-sheng; JIAO Jun; ZENG Xi; ZHANG Lan-hua (Department of Radiology;

DOI: 10.19367/j.cnki.1000-2707.2004.05.013

参考文献(References)：

• [1]张经济,连至诚,许冠荪,等.结肠运动的发生与调节[M].消化道病理生理学,广州:科技出版社,1997.1084-1090.
• [2]陈廷,王学勤,戴菲,等.不透X线标记物检测胃肠运动的临床应用[J].实用放射学杂志,2001,17(9):647-649.
• [3]ArharP ,DeveroedeG ,JehanninG ,etal.Segmentalcolonictransittime[J].DisColonRectum,1981,24:625.
• [4]VanAsscheG ,DeportereⅠ,ThijsT ,etal.ContractileeffectsandintracellularCa2+ signalinginducedbymotilinandery thromycininthecircularsmoothmuscleofhumancolon[J].NeurogastroenterolMotil,2001,13(1):27-35.
• [5]王志均.胃肠激素[M].北京:科学出版社,1985.210-307.
• [6]刘世信,张殿文,吴菲,等.结肠运输试验对诊断便秘的价值[J].中华医学杂志,1993,73(2):75.
• [7]WexnerSD ,DanielN ,JagelmanDG .Colectomyforconstipa tion:PhysiologicinvestigationisthekeytosucceVIP[J].DisColonRectum,1991,34(10):851.
• [8]中华医学杂志编委.便秘诊冶暂行标准[J].中华医学杂志,1991,71(10):549-550.
• [9]潘世友,曹长贵,段胜,等.结肠运输试验的临床运用[J].中国肛肠病杂志,1995,(1):7-9.
• [10]王毅,吴少平,龚水根.结肠运输试验及排粪造影对便秘的诊断[J].临床放射学杂志,1998,17(2):99-102.
• [11]柯美云,李若群,潘国宗,等.胃肠通过时间测定及其生理和病理意义的探讨[J].中华内科杂志,1990,12(29):723-726.
• [12]高利利,吴本俨,邵勇,等.老年特发性便秘患者结肠动力学变化[J].中国肛肠病杂志,2001,21(1):9-12.
• [13]陈泮藻,李振甲,郝秀华,等.胃动素快速放射免疫分析及初步临床应用[J].中华医学检验杂志,1990,13(5):279-281.
• [14]黄裕新,许才,冯英明,等.西安市正常人空腹血浆胃动素含量放免测定[J].第四军医大学学报,1991,12(6):477-478.
• [15]JenssenTG ,BurholPG ,JordeR ,etal.RIAplasmamotilininman[J].ScandJGastroenterrol,1984,19(6):717-723.
• [16]ChristofiedsND ,BloomSR ,BestermanHS .Physiologyofmotilin11[M].In:BloomSR ,ED .Guthormones[M].2nded.Edinburgh:ChurchillLivingstone,1978.343-350.
• [17]陈元方,陆国均,侯雪.血管活性肠肽的放射免疫分析[J].中华核医学杂志,1986,6(1):18-20.
• [18]黄振平,林莲初,鲍正毅.冠心病患者血浆中6种神经肽水平的临床研究[J].临床医学免疫,1999,7(6):78-81.
• [19]李君曼,李学会,陈建,等.肝硬化患者的胃排空障碍与血浆胃肠激素变化的关系[J].中华消化杂志,1997,17(6):359-360.
• [20]周吕,柯美云.胃肠动力学基础与临床[M].北京:科学出版社,1994.126-149.
• [21]姜若兰.胃肠激素与胃肠运动[J].中华消化杂志,1996,16(6):353-355.
• [22]AkandeB .ReleaseofsubstanceP likeimmunoreactivitybyamealandbombesin[J].Regulatorypeptides,1980,(suppl):1.
• [23]ModlinIM ,BloomSR ,EdinburghED ,etal.Thesystemicre leaseandpharmacokineticsofVIP ,inGuthormones[J].ChurchillLivingstone,1978.470.
• [24]MoriseK ,FurusawaA ,YamamatoH ,etal.Roleofguthor monesinirritablebowelsyndrome[J].NipponRinsho,1992,50(11):2697.
• [25]陈元方.胃肠激素与胃肠运动[J].国外医学消化系疾病分册,1992,12(1):1-6.
• [26]ScheurerU ,DrackE ,HalterF .SubstancePactivatesratcolonicmotilityviaexcitatoryandinhibitoryneuralpath waysanddirectactiononmuscles[J].JPharmacolExpTher,1994,271(1):7.

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