贾镭,高梅,马洪波,王咏梅,王长文,宋春梅,杨中万
JIA Lei; GAO Mei; MA Hong-bo; WANG Yong-mei; WANG Chang-wen; ;SONG Chun-mei;

• 1:第四军医大学吉林军医学院
• 2:第四军医大学吉林军医学院
• 3:第四军医大学吉林军医学院
• 4:第四军医大学吉林军医学院

摘要(Abstract)：

目的:探讨5km重复低压不缺氧对小鼠肝脏及脾脏中微量元素的影响。方法:小白鼠分2组,5km低压不缺氧30min组(实验组)及地面对照组。实验组5km低压不缺氧30 min,连续7 d后,处死小鼠,取肝脏、脾脏烘干至恒重,采用火焰原子吸收法测定锌、铜、铁。结果:实验组小鼠肝脏和脾脏中Fe、Cu、Zn降低,与对照组比较有差异(P<0.05)。结论:5km重复低压不缺氧,使肝脏和脾脏中Fe、Cu、Zn含量降低,可能是由于低气压使机体产生胃肠胀气而影响了胃肠道的消化吸收。提示飞行人员膳食中应适当增加 Fe、Cu、Zn供给。
Objective: To probe into the influence of repeated hypobaric non - hypoxia on the contents of trace elements in the liver and spleen of mice. Methods: 20 mice were divided into experimental (EX) and control (CO) groups (10 in each). During the 7 days of the experiment, every day, mice in EX group stayed in the chamber simulating 5 Km altitude for 30 min, while hypobaric non - hypoxia was supplied with oxygen. At the 8th day, all of the 20 mice were executed, and the livers and spleens were oven dried to test their weight. Atomic absorption spectrophotometry was used to detect the contents of Zn, Fe, and Cu in the liver and spleen. Results; The liver contents of Fe, Cu, and Zn were significantly lower in EX group than those in CO group (P <0. 05) , and the spleen contents of Zn and Cu were significantly lower in EX group than those in CO group (P <0. 05 ) . Conclusions: The repeated hypobaric non - hypoxia at the altitude of 5km can reduce the liver contents of Cu, Zn and Fe, and the spleen contents of Cu and Zn of mice. The results indicate that it is important to properly increase the supply of Fe, Cu, and Zn in the diet of aviators.

关键词(KeyWords)： 低气压;肝;脾;元素;微量化学
hypobaria; liver; spleen; elements; nlicrochemistry

Abstract:

Keywords:

基金项目(Foundation): 军队医药卫生科研基金(KH990180)

作者(Authors): 贾镭,高梅,马洪波,王咏梅,王长文,宋春梅,杨中万
JIA Lei; GAO Mei; MA Hong-bo; WANG Yong-mei; WANG Chang-wen; ;SONG Chun-mei;

DOI: 10.19367/j.cnki.1000-2707.2003.02.011

参考文献(References)：

• [1] 刘俊英,范明,张经伦,等.不同高度急性低压缺氧时大鼠脑组织腺苷三磷酸酶及琥珀酸脱氢酶变化[J」.中华航空航天医学杂志,1996,7(2) :72-74．
• [2] 马诺山,王大鹏,常国有,等.急性低压缺氧对大鼠多种心血管活性物质的影响[J].中华航空航天医学杂志,1999,10(4) :209-211．
• [3] Yanagiswa M, Kurihara H, Kimura S, et al. A novel potent vasocosntrictor peptide produced by vascular endothelial cells [ J ]. Nature, 1988,332:41 1--412．
• [4] 刘铁汉,常耀明,罗新林.航空营养与食品卫生学[M].西安:第四军医大学出版社,1988． 48．
• [5] 颜世铭,曹光辉,熊丽辉,等.微量元素与机体防御机制[1] .世界元素医学,1998,5(2) :

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