吴伦宽，黄燮南，刘国雄，吴芹
Wu Lunkuan et al(Departmant Pharmacology;

• 1:贵阳医学院附属医院心内科，遵义医学院药理学教研室

摘要(Abstract)：

静注羟自由基（·ＯＨ）生成液０．５ｍ·１００ｇ~（－１），使麻醉大鼠心功能明显受损，表现为左室收缩期峰值压（ＬＶＳＰ）及其与心率的乘积（ＬＶＳＰ×ＨＲ）、平均动脉压（ＭＡＰ）、左室等容收缩期最大上升和下降速率（＋ｄＰ／ｄｔｍａｘ和－ｄＰ／ｄｔｍａｘ明显降低，而左室舒张末期压（ＬＶＥＤＰ）显著升高，在给·ＯＨ前５ｍｉｎ静注地诺帕明（Ｄｅｎｏ）１８μｇ·１００ｇ~（－１），再以３μｇ·１００ｇ~（－１）·ｍｉｎ~（－１）于给·ＯＨ后立即静脉输注，可不同程度地改善上述异常血流动力学指标，基中对ＬＶＥＤＰ改善尤为显著。Ｄｅｎｏ还明显对抗·ＯＨ所致血浆丙二醛含量的升高。
The effects of denopamine (Deno) on the abnormal hemodynamics induced by exogenous hydroxyl free radical (·OH) were investigated in anaesthetized rats. Intravenous administration of ·OH-generating solution ( H2O2 1 mmol with equimolar CuCl2 and vitamin C) 0. 5ml·100g1 significantly decreased LVSP,LVSP×HR, MAP, +dP/dtmax and -dP/dtmax, and increased LVS in anaesthetized rats. These effects maintained for the whole surveying period (1h). Preadministration (iv, 5 min before·OH) of Deno 18 μg·100-1 followed by intravenous infusion of 3μg.100g-1.·min-1 after administration of·OH significantly improved these abnormal hemodynamic indices induced by ·OH except EVSP which tended to be improved by Deno, the improvement of LVEDP was specifically significant. Ferthermore, the heightened serum malondialdehyde (MDA) content induced by ·OH was also decreased by Deno. The clinical significance was discussed.

关键词(KeyWords)： 地诺帕明，羟自由基，血液动力学，丙二醛，大鼠
denopamine; hydroxyl free radical; hemodynamics; malondialdehyde; rats

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 吴伦宽，黄燮南，刘国雄，吴芹
Wu Lunkuan et al(Departmant Pharmacology;

DOI: 10.19367/j.cnki.1000-2707.1994.02.002

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