贵州医科大学学报

1990, (03) 211-214

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肝硬化患者血浆心钠素、肾素活性、血管紧张素II及醛固酮水平的初步研究
Preliminary Studies of Plasma Atrial Natriuretic Factor, Renin Activity, Angiotensin Ⅱ and Aldosterone in Cirrhotic Patients

周力;佃霉辉;张文田;李培;卢源;姚淙;杨京;罗永芳;
Zhou Li Department of Internal Medicine

摘要(Abstract):

作者用放射免疫法测定了41例肝硬化患者及50例健康人的血浆心钠素、肾素活性、血管紧张素Ⅱ及醛固酮含量。结果表明,肝硬化腹水时上述指标均明显升高且与病情相关。在有腹水的患者,肾素活性、血管紧张素Ⅱ及醛固酮测定可作为估计疗效、判断预后的良好指标。这些患者的心钠素与肾素、血管紧张素Ⅱ或醛固酮之间无明显相关,提示肝硬化时这几种激素的释放、代谢调控发生紊乱。
The levels of the plasma atrial natriuretic factor renin activity angioten- sin Ⅱ and aldosterone were studied in three grcups of patients with cirrhosis of the liver. Group Ⅰincluded 14 Patients, without ascite; Group Ⅱ 14 patie- nts with minimal to moderate ascites Group Ⅲ 13 patients with tense ascites. When compared with normal controls, the mean levels of Plasma atrial natriu- retic factor, renin, angiotensin Ⅱand aldosterone in cirrhotie patients were si- gnificantly elevated. The difference was particularly significant for group Ⅱ and Ⅲ (p<0.01) Although in groupⅠpresented slightly higher values than those of normal controls but without statistical siqnificance (p>0.05). The results showed that there were not any correlations between plasma atrial natriuretic factor and renin, angioensin Ⅱ or aldosterone (p>0.05). The Pathogenesis of increasing of these hormones in cirrhotic patients is discussed by the authors.

关键词(KeyWords): 肝硬化;肾素;血管紧张素Ⅱ;醛固酮
cirrhosis of liver;plasma renin;angiotensin Ⅱ(ATⅡ);aldosterone(ALD);atrial natriuretic factor (ANF)

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作者(Author): 周力;佃霉辉;张文田;李培;卢源;姚淙;杨京;罗永芳;
Zhou Li Department of Internal Medicine

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DOI: 10.19367/j.cnki.1000-2707.1990.03.012

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