制订医学诊断参考值的混杂样本剖析法——Weibull分布在医学中的应用A METHOD OF DISSECTING MIXED SAMPLES FOR ESTIMATING THE REFERENCE VALUES OF MEDICAL DIAGNOSIS
王绍鑫
Wang Shaoxin Department of Health Statistics
摘要(Abstract)：
本文以 Weibull 分布为数学模型,提出了:(1)以 Marquardt 非线性最小二乘法估计参数的剖析法;(2)一个系统的混杂样本剖析,参考值制订及相应假阴性率、漏诊率和误诊率估计的计算程序。通过剖析一临床资料,证实了本法的可靠性和可行性。
In this paper,we basing on the mathematical model of Weibull distribu- tions,present:(1).the Marquardt's nonlinear least square dissecting method; (2)a systematic computerized program for the dissection of mixed samples, the determination of reference values and the estimation of false-negative per- centages as well as the rate of mis-diagnosis and false-diagnosis.The results obtained from one clinical trial demonstrate that there is quite a agreement in the distribution and the reference values between the dissected and the control samples.The result is reliable and the method applicable in clinical practice.
关键词(KeyWords)：
参考值;混杂样本;Weibull 分布;数学模型;参数估计
Reference values;Mixed samples;Weibull distribution;Mathematical model;Parameter estimation
基金项目(Foundation):
作者(Author):
王绍鑫
Wang Shaoxin Department of Health Statistics
DOI: 10.19367/j.cnki.1000-2707.1988.02.030
参考文献(References)：
- 1． Hoffmann RG.Statistics in the practice of medicine.JAMA 1963;185:864．
- 2． Ginder EM.Caculation of normal ranges by methods used resolution of overlapping Gaussian distribution.Clin Chem 1970;16:124．
- 3． Prince AM.The use of serum enzyme determinations to detect anicteric hepatitis.Transfusion 1965;5:120．
- 4． Fraser RD.Resolution of overlapping abruption bands by least squares procedures.Anal Chem 1966;38:1770．
- 5． Martin HF.Normal values in clinical chemistry.New York:Marcel Dekker Inc,1975:214-352．
- 6． 杨珉.确定医学正常值的混杂样本剖析法.中国预防医学杂志 1983;17(5) :275．
- 7． 杨树勤,主编.中国医学百科全书.医学统计学.上海:上海科学技术出版社,1985:193～196．
- 8． 杨树勤,等医学正常值的统计方法专题笔谈.中国卫生统计1985;2(2) :1．
- 9． 冯康,等.数值计算方法.北京:国 防工业出版社,1978:154～156．
- 10． 曾秋成.技术数理统计方法.合肥:安徽科技出版社,1983:101～104．
文章评论(Comment)：
|
||||||||||||||||||
|
||||||||||||||||||