贵州医科大学学报

2009, v.34;No.v.34(04) 396-398

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原发性高血压患者血清C反应蛋白的变化
Changes of Serum C-reactive Protein in Patients with Essential Hypertension and Its Clinical Importance

王淑琴;付青梅;刘兴德;
WANG Shuqin,FU Qingmei,LIU Xingde (Department of Cardiac Internal Medicine,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:观察原发性高血压(EH)患者血清C反应蛋白(CRP)的变化,探讨CRP与EH的关系及其临床意义。方法:运用酶联免疫吸附法(ELISA)测定100例EH患者和28例对照组人群的血清CRP,100例EH患者中,单纯EH41例,合并冠心病(CHD)59例;非极高危EH11例,极高危EH89例。41例单纯EH中,极高危EH30例,其中2级EH13例,3级EH17例;中年EH22例,老年EH19例。结果:(1)EH组血清CRP含量显著高于对照组(P<0.05);(2)3级EH组血清CRP含量显著高于2级组(P<0.05),2级EH组血清CRP含量显著高于对照组(P<0.05);EH极高危组血清CRP含量显著高于非极高危组(P<0.05),EH非极高危组血清CRP含量显著高于对照组(P<0.05);(3)老年EH组血清CRP含量显著高于中年组(P<0.05),中年组血清CRP含量显著高于对照组(P<0.05)。结论:(1)CRP可能与EH有关;(2)CRP可能参与了EH的分级和危险分层;(3)CRP可能与EH患者的年龄有关。
Objective: To observe the changes of serum C-reactive protein(CRP) in patients with essential hypertension(EH) and to study the relationship between CRP and EH,and its clinical significance.Methods: Circulating CRP concentrations of 100 patients with EH(experimental group,group E) and 28 patients with no EH(control group,group C) were measured with enzyme-linked immunosorbentassay(ELISA) method,and coronary angiography was operated on all of the patients.Results: CRP in patients of group E was significantly higher than that of group C(P<0.05);CRP in patients of grade 2 in group E was significantly higher than that of group C(P<0.05);Within group E,CRP of grade 3 patients was obviously higher than that of grade 2 patients(P<0.05),and CRP of highest risk patients was markedly higher than that of non risk patients(P<0.05),while CRP of non-high risk patients was statistically higher than that of patients in group C(P<0.05);CRP in older patients was higher than that in middle-aged patients which was higher than that of group C.Conclusions:(1)CRP might be correlated to EH;(2) CRP might participate the process of blood pressure grading and the delamination of risk factors;(3) There is some correlation between EH and patient age.

关键词(KeyWords): 高血压;C反应蛋白;炎症;酶联免疫吸附测定
hypertensio;C-reactive protein;inflammation;enzyme-linked immunosorbenassay

Abstract:

Keywords:

基金项目(Foundation): 贵阳市科学技术计划项目[(2006)筑科农字27-5号];; 贵州省卫生厅科学技术基金项目[黔卫发(2006)130-6号]

作者(Author): 王淑琴;付青梅;刘兴德;
WANG Shuqin,FU Qingmei,LIU Xingde (Department of Cardiac Internal Medicine,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2009.04.012

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