西酞普兰及其代谢物的对映体稳态血药浓度Analysis of State Plasma Concentrations of Enantiomers of Citalopram and its Metabolites in Elder Patients
郑志昌,UlrichKlotz
Zheng Zhichang ; Ulrich Klotz Department of Pharmacy;
摘要(Abstract)：
测定了 16例老年抑郁症患者口服西酞普兰 (Citalopram ,CIT)后CIT及其代谢物对映体的稳态波谷血药浓度。结果表明 ,口服 2 0mg/d后 (n =14 ) ,R CIT和S CIT的平均稳态浓度分别为 ( 36 2± 15 0 ) μg/L和 ( 2 7 4± 13 1) μg/L ,R DM CIT和S DM CIT分别为 ( 7 2± 3 1) μg/L和( 7 7± 3 8) μg/L ;口服 4 0mg/d后 (n =2 ) ,CIT和去甲西酞普兰 (DM CIT)浓度有高于前者的趋势 ;去二甲西酞普兰 (DDM CIT)仅在 8例患者中测出R DDM CIT。R CIT与S CIT ,R DM CIT与S DM CIT以及R CIT与R DDM CIT间存在线性正相关
In this paper the state plasma concentrations of enantiomers of citalopram and its metabolites in 16 elder depressive patients were determined by a stereoselective HPLC method. The result showed that for the dose of 20 mg per day (n=12) the mean values ±SD of R-CIT and S-CIT plasma concentrations were (36.2±15.0) μg/L and (27.4±13.1) μg/L respectively, for R- (and S-DM-CIT) (7.2±3.1) μg/L and (7.7±3.8) μg/L respectively, whereas DDM-CIT was only detectable as R-enantiomer in 8 cases. For the dose of 40 mg per day, there was seemly a tendency of higher plasma concentrations of CIT and its metabolites than the former with lower dose. Significant (P<0.01) linear correlation could be found between both enantiomers of CIT and DM-CIT as well as between the parent drug and primary metabolite for R-enantiomer.
关键词(KeyWords)：
西酞普兰;抑郁症;老年人;对映体;稳态血药浓度
citalopram; depression; aged; enantiomers; state plasma concentration
基金项目(Foundation):
作者(Authors):
郑志昌,UlrichKlotz
Zheng Zhichang ; Ulrich Klotz Department of Pharmacy;
DOI: 10.19367/j.cnki.1000-2707.2000.03.007
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