李凡,叶兰,孟剑湃,曾强
LI Fan1,YE Lan2,MENG Jianpai2,ZENG Qiang1(1.International Medical Center

• 1:解放军总医院国际医学中心
• 2:贵阳医学院药理学教研室

摘要(Abstract)：

目的:探讨血管紧张素II受体拮抗剂(ARB)坎地沙坦对自发性高血压大鼠(SHR)炎性因子水平及胰岛素抵抗的影响。方法:30只SHR随机分为模型组、坎地沙坦高剂量组及低剂量组,10只WKY大鼠作为对照组,4组大鼠均给与果糖喂养,高、低剂量组同时给与对应剂量的坎地沙坦灌胃干预,8周后观察各组大鼠血压、胰岛素抵抗指数和炎性因子IL-2、IL-6、CRP的水平。结果:模型组大鼠血压、胰岛素抵抗指数及血清IL-6、CRP均较对照组升高,差异有统计学意义(P<0.01);坎地沙坦干预的大鼠与模型组大鼠相比,以上指标则明显降低,差异有统计学意义(P<0.05)。结论:坎地沙坦可能通过降低炎性因子IL-6、CRP的水平来改善胰岛素抵抗。
Objective: To investigate the effects of candesartan on inflammatory cytokines and insulin resistance in spontaneously hypertensive rats(SHR).Methods: Thirty SHR were randomly divided into model group(group M),high dose of candesartan group(group H) and low dose of candesartan group(group L).Ten WKY rats served as control group.All rats were fed with fructose,while the rats in groups L and H were given corresponding doses of candesartan by gavage.After 8 weeks,blood pressure,insulin resistance index and serum levels of inflammatory cytokines including IL-2,IL-6 and C-reactive protein(CRP) of rats in the 4 groups were detected.Results: The blood pressure,insulin resistance index and serum levels of IL-6 and CRP in group M were significantly higher than those of control(P<0.01).With the treatment of candesartan,the indicators mentioned above were decreased significantly in groups L and H(P<0.05).Conclusions: Candesartan may improve insulin resistance by reducing the serum inflammatory cytokines IL-6 and CRP levels.

关键词(KeyWords)： 高血压;坎地沙坦;胰岛素;白细胞介素-2;白细胞介素-6;C反应蛋白质
hypertension;candesartan;insulin;interleukin-2;interleukin-6;C-reactive protein

Abstract:

Keywords:

基金项目(Foundation): 北京市自然科学基金资助项目(7122171)

作者(Author): 李凡,叶兰,孟剑湃,曾强
LI Fan1,YE Lan2,MENG Jianpai2,ZENG Qiang1(1.International Medical Center

DOI: 10.19367/j.cnki.1000-2707.2012.03.014

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