贵州医科大学学报

2011, v.36;No.153(06) 592-594

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抗抑郁剂治疗2型糖尿病痛性神经病变伴抑郁症疗效分析
Clinical Effects of Anti-depression Treatment on Type 2 Diabetes Mellitus Patients with Painful Neuropathy and Depression

周勤梅;
ZHOU Qinmei (Department of Pharmacy,People's Hospital of Tongliang County,Tongliang 402560,Chongqing,China)

摘要(Abstract):

目的:探讨抗抑郁剂治疗2型糖尿病痛性神经病变伴抑郁症的疗效。方法:将64例2型糖尿病痛性神经病变患者随机分为治疗组(33例)和对照组(31例),对照组进行常规治疗,治疗组在此基础上加用抗抑郁药物西酞普兰;以汉密尔顿抑郁量表(HAMD-17)评定患者治疗前后抑郁程度,汉密尔顿焦虑量表(HAMA)评估焦虑程度,数字疼痛分级法(NPIS)评估疼痛改善情况,测定糖化血红蛋白(HbAlC)评估糖尿病控制效果。结果:入组前两组HAMD和HAMA评分的差异没有统计学意义;治疗2、4、8、12周后,治疗组HAMD和HAMA评分较治疗前好转,较对照组明显改善,治疗组治疗12周后HbA1c水平明显低于对照组,治疗14 d后,治疗组的NPIS评分明显低于治疗前和对照组。结论:抗抑郁治疗不仅可缓解2型糖尿病痛性神经病变伴抑郁症患者的抑郁症状,还有益于疼痛的缓解。
Objective: To investigate the therapeutic efficacy of anti-depression treatment on type 2 diabetes mellitus(DM) patients with painful neuropathy and depression.Methods: A total of 64 type 2 diabetes patients with painful neuropathy were randomly divided into control group(group C,n=33) and treatment group(group T,n=31).The patients in group C received routine treatment,and the patients in group T received both routine and citalopram antidepressant treatment for 14 days.Hamilton Depression Rating Scale(HAMD-17) was used to assess depressive degree,and Hamilton Anxiety Scale(HAMA) was used to assess degree of anxiety,and numeric pain intensity scale(NPIS) was used to assess pain symptoms.Results: Before treatment,no significant difference of HAMD and HAMA scores between the two groups was found.After treatment for 2,4,8 and 12 weeks,HAMD and HAMA scores in group T were better than those before treatment and than those in group C.NPIS scores in group T in 14 days of treatment were significantly lower than those before treatment and than those in group C.After treatment for 12 weeks,HbA1c levels in group T were significantly lower than those in group C.Conclusions: Anti-depression treatment is effective not only in controlling depression symptoms but also in pain relief in type 2 DM patients with painful neuropathy.

关键词(KeyWords): 糖尿病,非胰岛素依赖型;糖尿病神经病变;抗抑郁药
diabetes mellitus,non-insulin-dependent;diabetic neuropathies;antidepressive agents

Abstract:

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作者(Author): 周勤梅;
ZHOU Qinmei (Department of Pharmacy,People's Hospital of Tongliang County,Tongliang 402560,Chongqing,China)

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DOI: 10.19367/j.cnki.1000-2707.2011.06.014

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