贵州医科大学学报

1984, (03) 3-5

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健康老年人个体外周血液自然杀伤细胞活性的研究
NATURAL KILLER CELL-ME-DIATED CYTOTOXICITY IN OLD INDIVIDUALS

李永琴;庄宗杰;桂华珍;刘家骝;
Li Yongchin, Department of Pathology

摘要(Abstract):

<正> 自然杀伤细胞(NK细胞)是存在于■啮动物和人体内的一类不需要经过抗原致敏不依赖抗体和补体介导对靶细胞有直接杀伤作用的淋巴细胞亚群。由于NK细胞能够非特异地识刚病毒、八侵的细菌等感染性病原体和外源性细胞、肿瘤细胞对机体抗感染和免疫监视等功能起重要作用。近十年来国外对NK细胞的生物学性状与效应有一些报道,国内有少量报告。我们研究了老年个体NK细胞活性以及性别对NK细胞活性的影响,现报道如下:
release assay has been used to detect the natural killer cell-mediated cyto- toxicity. Using K562 cell Iine as the target cell, we have observed the natural killer activity of the mono- nuclear cells from the peripheral blood of 355 normal subjects. The mean level of NK activity in the group above 60 year of age was si- gnificantly lower than that of the 18-59 year aged group ( P<0.05)while there was no significant difference either between the more than 60 year aged group and the 1-17 year aged group or between the 18-59 year aged group and the 1-17 year aged group (P>0.05). The NK activity in adult males (35.3±17.06)。was significantly higher than in adult females (28.12± 17.68)。This indicates that the sexual hormones modulates the NK activity.

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作者(Author): 李永琴;庄宗杰;桂华珍;刘家骝;
Li Yongchin, Department of Pathology

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DOI: 10.19367/j.cnki.1000-2707.1984.03.003

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