贵州医科大学学报

2011, v.36;No.150(03) 269-272

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贺苏对创伤失血性休克伴颅脑损伤早期血流动力学及淋巴细胞亚群的影响
Early Effect of Hesu on Hemodynamics and Lymphocyte Subsets in Traumatic Hemorrhagic Shock Accompanied by Craniocerebral Injury

杜奇容;刘鸣;潘曙明;黄四平;陈凯骏;康健;
DU Qirong,LIU Ming,PAN Shuming,HUANG Siping,CHEN Kaijun,KANG Jian (Department of Emergency Center,the Affiliated Xinhua Hospital of Medical College of Shanghai Jiaotong University,Shanghai 200092,Shanghai,China)

摘要(Abstract):

目的:探讨贺苏对创伤失血性休克伴颅脑损伤早期血流动力学及淋巴细胞亚群的影响。方法:70例患者随机分为贺苏组和对照组,观察用药前后血流动力学、血星形胶质源性蛋白(S100B)、免疫功能、凝血功能、电解质、肝肾功能及格拉斯哥昏迷评分(GCS)的改变。结果:(1)治疗后血压均明显上升,贺苏组上升更快更明显(P<0.05);(2)贺苏组用药后2 h的GCS评分明显提高,血S100B明显低于对照组(P<0.05);(3)贺苏组免疫功能的恢复明显优于对照组(P<0.05);(4)两组凝血功能、电解质及肝肾功能在治疗后无异常。结论:贺苏早期对创伤失血性休克能进行有效复苏,而且能显著减轻颅脑损伤引起的病情的恶化,改善机体的免疫功能。
Objective:To investigate the early effect of Hesu(a 200/0.5 injection of 7.2% hypertonic saline plus 6% hydroxyethyl starch) on hemodynamics and lymphocyte subsets in traumatic hemorrhagic shock accompanied by craniocerebral injury.Methods:Seventy patients were randomly divi-ded into Hesu group(group H) and control group(group C).The changes of hemodynamics,blood S100B,function of immune system,blood coagulation,electrolytes,renal and hepatic functions and Glasgow coma score(GCS) were observed before and after treatment.Results:(1) Blood pressure of the two groups increased significantly after treatment,and the increase in group H was faster and more significant(P<0.05);(2) In group H,GCS was significantly increased in 2 hours after treatment and S100B was lower than that in group C(P<0.05);(3) The recovery of immune function in group H was better than that of group C(P<0.05);(4)The indexes of coagulation,electrolytes,hepatic and renal functions were as normal in group H after infusion of Hesu as those in group C.Conclusion:Hesu is not only effective in the resuscitation of patients from traumatic hemorrhagic shock,but also can lessen deterioration of brain injury and improve immune function.

关键词(KeyWords): 贺苏;休克,出血性;颅脑损伤;血流动力学;淋巴细胞亚群
Hesu;shock,hemorrhagic;craniocerebral trauma;hemodynamics;lymphocyte subsets

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作者(Author): 杜奇容;刘鸣;潘曙明;黄四平;陈凯骏;康健;
DU Qirong,LIU Ming,PAN Shuming,HUANG Siping,CHEN Kaijun,KANG Jian (Department of Emergency Center,the Affiliated Xinhua Hospital of Medical College of Shanghai Jiaotong University,Shanghai 200092,Shanghai,China)

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DOI: 10.19367/j.cnki.1000-2707.2011.03.014

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