孙萍,杜立,赵萍
SUN Ping,DU Li,ZHAO Ping(Department of Neurology

• 1:贵阳市第二人民医院神经内科
• 2:贵阳市第二人民医院神经内科
• 3:贵阳市第二人民医院神经内科 贵州贵阳550003
• 4:贵州贵阳550003

摘要(Abstract)：

目的:探讨脑出血诱发脓毒症综合征(全身炎症反应综合征)与肿瘤坏死因子-α(TNF-α)和白细胞介素6(IL-6)的关系。方法:观察72例急性脑出血患者并发非感染性系统性全身炎症反应综合征(SIRS)的发生率,并应用双抗体夹心(ELISA)法测定其血清TNF-α,IL-6的动态变化,以20名健康人作为对照。结果:脑出血时并发SIRS的发生率为47.2%(34/72),单纯脑出血组,脑出血致SIRS组患者血清TNF-α,IL-6含量均明显高于正常对照组(P<0.01)。结论:TNF-α,IL-6参与了脑出血并发SIRS的发生、发展的病理生理过程,并具有较高的预警价值。
Objective:To explore the systemic inflammatory response syndrome(SIRS)caused by acute cerebral hemorrhage and its relationship to serum tumor necrosis factor alpha(TNF-α)and Interleukin-6(IL-6).Methods:The occurrence rate of SIRS in 72 cases of acute cerebral hemorrhage was observed,and the contents of serum TNF-α and IL-6 of the patients were tested with ELISA as index to reflect their dynamic changes.Twenty normal healthy people were in control group.Results:The occurrence rate of cerebral hemorrhage accompanied by SIRS was 47.2%(34/72).The serum levels of TNF-α and IL-6 in simple cerebral hemorrhage group,and cerebral hemorrhage with SIRS group were obviously higher than those in control group(P<0.01).Conclusions:TNF-α and IL-6 may be involved in the onset and development of SIRS and have a high foretelling value to cerebral hemorrhage.

关键词(KeyWords)： 脑出血;脓毒症综合征;肿瘤坏死因子;白细胞介素6
cerebral hemorrhage;sepsis syndrome;tumor necrosis factor;interleukin-6

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 孙萍,杜立,赵萍
SUN Ping,DU Li,ZHAO Ping(Department of Neurology

DOI: 10.19367/j.cnki.1000-2707.2006.05.017

参考文献(References)：

• [1]李庆荣,龙治平.SIRS与MODS的相关性研究[J].中华实用医学,2001,3(13):36-38.
• [2]Menbers of the American College of Chest Physicians/Soci-ety of Critical Care Medicine Consensus Conference.Defi-nition for sep-pies in sepsis[J].Crit Care Med,1992(20):864-874.
• [3]中华神经科学会.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):370-380.
• [4]陈明生,朱瑞芳,詹庆盈.脑梗死患者血清TNF-α、IL-1β含量的变化及其临床意义的研究[J].中国神经免疫学和神经病学杂志,2001(8):32-34.
• [5]Qureshi AI,Suri MF,Ling GS,et al.Sbsence of cerly proinflam-matory cytokine expression in experimental in-tracerebral hemor-rhage[J].Neurosurgery,2001(49):416-420.
• [6]Godoy D,Boccio A,Hugo N.Systemic inflammatory re-sponse syndrome and primary of spontaneous intracerebral haemorrhage[J].Rev Neurol,2002(35):1101-1105.
• [7]Feuerstein GZ,Liu T,Barone FC.Cytokines,inflamma-tion and brain injury:role of tumor necrosis factor-α[J].Cerebrovasc Brain Metab Rev,1994(6):341-360.
• [8]Dziedzic T,Bartus S,Klimkowicz A,et al.Intracerebral hemor-rhage triggers interleukin-6and interleukin-10re-lease in blood[J].Stroke,2002(33):2334-2335.
• [9]Donovan FM,Pike CJ,Cotman CW,et al.Thrombin in-duces apoptosis in cultured neurons and astocytes via a pathway re-quiring tyrosine kinase and RhoA activities[J].Neurosci,1997(17):5316-5326.
• [10]Terregino CA,Quinn JV,Slotman GJ.Pilot study of cy-tokines in emergency department patients with systemic inflammatory re-sponse syndrome[J].Aced Emerg Med,1997(4):684-688.
• [11]袁志强,文亮,肖天利,等.危重病患者肿瘤坏死因子-α水平变化与APACHE II评分的关系[J].中国危重病急救医学,2000,12(4):236.
• [12]Gu r,kuida k,Tsutsui H,et al.Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme[J].Science,1997,275(5297):206.
• [13]Reinhart K,Menges T,Cardlund B,et al.Randomized,placebo-controlled trial of the anti-tumor necrosis factor antibody frag-ment afelimomab in hyperinflammatory re-sponse during severe sepsiss:the RAMSES study[J].Care Med,2001(29):765-769.
• [14]Spittler A,Razenberger M,Kupper H,et al.Relation-ship be-tween interleukin-6plasma concentration in pa-tients with sep-sis,monocyte phenotype,monocyte phag-ocytic properties,and cytokine production[J].Clin In-fect Dis,2000,31(6):1388-1420.

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