何燕,单可人,谢渊,吴昌学,赵艳,修瑾,齐晓岚,任锡麟
HE Yan; SHAN Ke-ren; XIE Yuan; WU Chang-xue; ZHAO Yan; XIU Jin; QI Xiao-lan; REN Xi-lin (Molecular Biological Key Laboratory of Guiyang Medical College;

• 1:贵阳医学院分子生物学重点实验室
• 2:贵阳医学院分子生物学重点实验室
• 3:贵阳医学院分子生物学重点实验室
• 4:贵阳医学院分子生物学重点实验室

摘要(Abstract)：

目的 :为预防和控制地中海贫血重症患儿的出生 ,对贵阳地区 5 4 5对孕期夫妇进行地中海贫血血液学筛查。方法 :采用地中海贫血一管定量筛查法 ,HbA2 、HbF定量法。结果 :对进行围产期检查的 5 4 5对孕期夫妇 (共 10 90例 )进行地中海贫血血液学筛查 ,检出阳性病例 4 3例 ,检出率为 3 94 % ,男女检出阳性率为 1 15∶1,其中夫妇双方均为阳性病例者 6对。结论 :在贵阳地区进行孕期夫妇的地中海贫血筛查工作 ,为产前基因诊断奠定了基础 ,对避免重症患儿的出生具有重要的社会意义。
Objective: In order to prevent and control the birthrates of thalassemia, to investigate the incidence of the disease among pregnant women and their spouses from Guiyang area. Methods: The one test tube quantitative method and HbA 2 and HbF quantitative method were used. Results: 43 cases with thalassemia were found among the 1 090 individuals. The positive rate was 3.94%. For the disease gene, the ratio of male carriers to female carriers was 1.15∶1. There were 6 couples that both husbands and wives were identified as carriers. Conclusion: The results of this research could be used as a reference for the fight of reducing the birthrate of thalassemia in Guiyang area.

关键词(KeyWords)： 地中海贫血;产前诊断;红细胞变形性;数据收集
thalassemia; prenatal diagnosis; erythrocyte deformability; data collection

Abstract:

Keywords:

基金项目(Foundation): 贵州省教委基金资助 (编号 :1 9980 0 1 )

作者(Authors): 何燕,单可人,谢渊,吴昌学,赵艳,修瑾,齐晓岚,任锡麟
HE Yan; SHAN Ke-ren; XIE Yuan; WU Chang-xue; ZHAO Yan; XIU Jin; QI Xiao-lan; REN Xi-lin (Molecular Biological Key Laboratory of Guiyang Medical College;

DOI: 10.19367/j.cnki.1000-2707.2004.02.008

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