王运红,郝玉杰,王桂英,高孝杰,田力铭
WANG Yunhong,HAO Yujie1,WANG Guiying,GAO Xiaojie,TIAN Liming(Department of Nephrology

• 1:迁安市人民医院肾内科
• 2:河北医科大学

摘要(Abstract)：

目的:观察肾康注射液联合厄贝沙坦对早期糖尿病肾病患者血清中瘦素(leptin)及脂联素(adipone-ctin)的影响。方法:将100例血压正常的早期糖尿病肾病患者随机分为对照组和治疗组,均给予糖尿病教育、饮食控制、适量运动及常规降糖治疗,使空腹血糖<7.0 mmol/L,餐后2 h血糖<10.0 mmol/L;对照组给予降糖药、胰岛素等常规西医治疗,治疗组在对照组治疗的基础上用肾康注射液100 ml加入5%葡萄糖250～300 ml静脉滴注,同时加2～3 U胰岛素加入5%葡萄糖200 ml,每天一次,并加用厄贝沙坦0.15 g,1次/d口服,3周为1疗程;全部病例观察9周,比较两组患者UREA、血清中瘦素、脂联素水平。结果:治疗9周后,治疗组血清瘦素降低、脂联素升高,与治疗前比较P<0.01;且明显优于对照组(P<0.05)。结论:肾康注射液联合厄贝沙坦可减少早期糖尿病肾病患者血清中瘦素,升高脂联素水平,对早期糖尿病肾病具有治疗作用。
Objective:To observe the influence of Shenkang injection combined with irbesartan on urinary albumin excretion rate(UAER)within 24 hours,serum leptin,and adiponectin of patients with early diabetic nephropathy.Methods: One hundred normotensive early diabetic nephropathy patients were randomly divided into control group(group C),and treatment group(group T).All of them were given diabetic education,dietary regimen,routine glucose-subduing treatment,and taken suitable movement till their fasting blood glucose(FBG) was less than 7.0 mmol/L and postprandial blood glucose(PBG) less than 10.0 mmol/L.Patients in group C were treated with oral anti-hyperglycemic agents or/and insulin,while those in group T,besides of treatment as control C,were given Shenkang injection 100ml mixed with 5% glucose 250～300 ml plus 2～3 U of insulin intravenously guttaed once a day,plus irbesartan 0.15 g once a day orally.A treatment course was 3 weeks and the experiment lasted 3 courses.The levels of UAER,serum leptin and adiponectin of the 2 groups were detected and compared.Results: UAER,and serum leptin of patients in group T after 9 weeks of treatment were significantly lower than those before and their adiponectin contents were increased(P<0.01).All the improvements were better than those in control group(P<0.05),of which the amelioration of the disease including decrease of UAER and serum leptin and increase of adiponectin was not obvious.Conclusions: Shenkang injection combined with irbesartan can reduce UAER,decrease serum leptin,and increase adiponectin,and has curative effect on diabetic nephropathy in earlier stage.

关键词(KeyWords)： 糖尿病肾病;肾素;厄贝沙坦;瘦素;脂联素
diabatic nephropathies;renin;irbesartan;leptin;adiponectin

Abstract:

Keywords:

基金项目(Foundation): 河北省中医药管理局科技管理项目资助(2009087)

作者(Author): 王运红,郝玉杰,王桂英,高孝杰,田力铭
WANG Yunhong,HAO Yujie1,WANG Guiying,GAO Xiaojie,TIAN Liming(Department of Nephrology

DOI: 10.19367/j.cnki.1000-2707.2010.02.008

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