贵州医科大学学报

1998, (03) 3-5

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Synthesis of γ-Aminobutyrate Derivatives
Synthesis of γ Aminobutyrate Derivatives

袁牧,钟裕国,庞其捷,李正化
Yuan Mu 1 Zhong Yuguo 2 Pang Qijie 2 Li Zhenghua 2 ( 1Department of Pharmacy, Guiyang Medical College,Guiyang, 550004 2School of Pharmacy, West China University of Medical Sciences)

摘要(Abstract):

生理条件下γ氨基丁酸不易透过血脑屏障,一个容易进入脑内的非毒性的γ氨基丁酸衍生物可能具有抗惊厥活性,为了增大γ氨基丁酸的脂溶性,使其能透过血脑屏障进入脑组织,作者通过亚胺键将γ氨基丁酸接到一个亲脂性载体上,设计并合成16个γ氨基丁酸衍生物,合成的化合物经元素分析、红外光谱、质谱和核磁共振氢谱检测,与目标化合物一致。
Under physiological conditions γ aminobutyric acid poorly crosses the blood brain barrier. It is likely that a nontoxic derivative of γ aminobutyric acid which easily enters the brain will have useful anticonvulsant activity. 16 derivatives of γ aminobutyric acid with an imine link to a lipophilic carrier were prepared. The synthesized compounds were confirmed to be corresponding to the target compounds by elementary analysis, IR,MS and 1 HNMR spectra.

关键词(KeyWords): γ-氨基丁酸,合成
γ Aminobutyric acid; Synthesis

Abstract:

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作者(Author): 袁牧,钟裕国,庞其捷,李正化
Yuan Mu 1 Zhong Yuguo 2 Pang Qijie 2 Li Zhenghua 2 ( 1Department of Pharmacy, Guiyang Medical College,Guiyang, 550004 2School of Pharmacy, West China University of Medical Sciences)

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DOI: 10.19367/j.cnki.1000-2707.1998.03.006

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