查力
Cha Li Guizhou Geriatric Institute

• 1: 贵州省老年医学研究所

摘要(Abstract)：

本文报告IT对高血压大鼠降压作用。结果对SHR有效,对CHR无效。SHR100mg/kg、150mg/kg po,1天1次,连续4wk,MAP、ASP、ADP均有不同程度降低,剂量增加作用更为明显,尤以ADP下降更显著,与对照组比较下降36.4％,对CHR无明显降压作用。SHR100mg/kg十二指肠给药,MAP下降以4h最为明显,与NF比较,其降压强度为1:1.03。SHR150mg/kgpo,1天1次4wk后,肝脏重量与对照组比较增加11.1％,SGPT升高7.1％,镜检无病理学变化,提示IT长期应用时应注意患者肝功的变化。IT降压机制可能与其拮抗Ca~(2+)有关。
Antihypertensive effects of isotetrandrine (IT) were compared with those of nifedipine (NF) by determining the mean arterial pressure (MAP), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and heart rate(HR) of anaesthetized SHR and cortison/saline hypertensive rats (CHR). (1)A dosage of 100 mg/kg IT, compared with antihypertensive effects during 4 h after duodenum administration of NF showed that the relative potencies of IT to NF 1.0 was 1.03 approximately. (2) Administering orally the IT at the dosage of 100mg/Kg, l50mg/kg by the once a day for 4 wk, the MAP was reduced 19.4%, 36.4% respectively in SHR, but has no significant effect on the CHR.(3)At the dosage of 100m/kg by the once a day oral administration for 4 wk, no significant effects were found on the body weight and weight of liver in SHR, while GPT was slightly elevated with 150mg/kg. The results suggest that IT appear significant antihypertensive effect. The mechanism of the antihypertensive effect of IT was belived to be related to its calcium blocking action.

关键词(KeyWords)： 高血压;依脉特灵;硝苯吡啶;钙通道阻滞剂
hypertensio;isotetrandrine;nifedipinc;calcium channel blockers

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 查力
Cha Li Guizhou Geriatric Institute

DOI: 10.19367/j.cnki.1000-2707.1991.02.005

参考文献(References)：

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• 2． 董会奕,等.异防己甲素治疗高血压病50例.贵阳医学院学报 1989;14(3) :210．
• 3． 松田三郎,上田元彦.新抗高血压药Pinacidil关药理学的研究.日本药理学杂志昭和60年;86(5) :341．
• 4． 朱延伟,等.异防己甲素毒性研究.中华劳动卫生职业病杂志 1985;1:34．

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