贵州医科大学学报

2000, (03) 235-237+240

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Ⅱ型糖尿病患者GAD-Ab和ICA联合检测及价值
A Preliminary Study on Significance of Combined Determination of GAD Ab and ICA in Type Ⅱ Diabetes Mellitus

叶秀兰,黄山,于瑞萍,周荣霞,莫晓虹,王亚林,董健,邓小林
Ye Xioulan , Huan Shan ,Yu Ruiping ,Zhou Rongxia , Mo Xiaohong , Wang Yalin , Do Jian, Deng Xiaolin Department of Endocrinology ,People's Hospital of Guizhou Province

摘要(Abstract):

对 91例Ⅱ型糖尿病患者及 2 8例正常人的血清 ,用ELLSA法测定谷氨酸脱羧酶抗体(GAD Ab)及胰岛细胞抗体 (ICA)。结果 :Ⅱ型糖尿病人中抗体阳性率为 30 76% ,GAD Ab阳性为17 50 % ,ICA阳性为 15 38% ,双抗体阳性为 2 19% ,对照组GAD Ab和ICA均为阴性 ;抗体阳性各组体重指数 (BMI)较阴性组明显降低 ,且有显著性差异 ;小于 4 0岁患者抗体阳性率最高 ( 60 % ) ;血清C肽水平从低至高依次为双抗体阳性组、GAD Ab阳性组、ICA阳性组、抗体阴性组。提示GAD Ab、ICA联合检测可提高诊断成人迟发性自身免疫性糖尿病 (LADA)敏感性 ;Ⅱ型糖尿病中小于 4 0岁起病及低BMI可作为诊断LADA的一个重要线索 ;β细胞受损程度可能与自身抗体的种数及种类有关
To evaluate the significance of glutamic acid decarboxylase antibody(GAD Ab) and islet cell antibody(ICA)determination in type Ⅱ diabetes mellitus . GAD Ab and ICA of 91 patients with type Ⅱ diabetes mellitus were measured with ELISA and serum C-peptide was measured with radioimmunoassay. The autoantibody positive rate was highter than that of GAD Ab (30.76% versus 17.50% P<0.01) and that of ICA (30.76% versus 15.38% P<0.01) in type Ⅱ diabetes mellitus. Body mass index(BMI) was lower in autoantibody positive groups than autoantibody negative group. The autoantibody positive rate was higher in ages<40 group than those in other ages groups. The serum C-peptide leve was double antibody positive group

关键词(KeyWords): 谷氨酸脱羧酶;胰岛;抗体;糖尿病;非胰岛素依赖型
glutamate decarboxylase; islets; antibodies; diabetes mellitus,non-insulin-dependent

Abstract:

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作者(Author): 叶秀兰,黄山,于瑞萍,周荣霞,莫晓虹,王亚林,董健,邓小林
Ye Xioulan , Huan Shan ,Yu Ruiping ,Zhou Rongxia , Mo Xiaohong , Wang Yalin , Do Jian, Deng Xiaolin Department of Endocrinology ,People's Hospital of Guizhou Province

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DOI: 10.19367/j.cnki.1000-2707.2000.03.006

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