刁晓艳,孙宁玲,于仲元
DIAO Xiao-yan~1,SUN Ning-ling~1,YU Zhong-yuan~2(1.Department of Cardiology

• 1:北京大学人民医院心内科
• 2:北京大学人民医院心内科
• 3:北京大学人民医院肾内科 北京100044北京大学博士研究生现工作单位为贵阳医学院附院心内科
• 4:北京100044

摘要(Abstract)：

目的:探讨慢性肾功能衰竭患者不同阶段肾上腺髓质素(ADM)的特点及其与系统血管顺应性(SVC)的关系。方法:采用放射免疫法测定19例终末期肾病(ESRD)长期透析患者和15例慢性肾功能衰竭(CRF)尚未透析患者的ADM水平,同时所有患者均采用Dynapu lse200M动脉功能测定仪检测SVC,并和15例正常人作对照。比较13例ESRD透析患者透析前后的ADM的变化并分析了ADM与SVC的关系。结果:与正常对照组比较,CRF组和透析组患者的ADM明显增高(P<0.01),透析组与CRF组比较,透析组的ADM比CRF组明显升高(P<0.01)。透析后即刻SVC明显的改善(P<0.01),ADM明显增加(P<0.05),而透析后5 h,SVC、ADM与透析前比较无明显变化(P>0.05),SVC的变化与ADM无明显相关性。结论:慢性肾衰患者ADM明显增高,透析中ADM的变化是暂时的,与SVC无明显相关性。
Objective: To investigate properties of adrenomedullin(ADM) in chronic renal failure patients at different disease stages and their relationship with systemic vascular compliance(SVC).Methods: ADM levels in 19 hemodialysis(HD) patients with end-stage renal disease(ESRD),and 15 patients with chronic renal failure(CRF) but not receiving dialysis therapy were detected by radioimmun-oassay(RIA).SVC of all patients and 15 normal people(as control) were detected by Dynapulse 200M.ADM levels at pre-,post-and 5 hours after-HD of 13 chronic HD patients were measured and compared.Results: Compared with normal,ADM level increased in CRF and HD patients(P<0.01),ADM level of HD patients were higher than that of CRF patients(P<0.01).Significant SVC decrease and ADM increase occurred right after the dialysis(P<0.01,P<0.05).However,in 5 hours after HD,SVC and ADM changed back to the level before HD(P>0.05).No significant correlation was found between SVC and ADM(P>0.05).Conclusions: ADM of chronic renal failure patients increases significantly;The changes of ADM caused by HD are reversible;SVC and ADM had no significant relationship.

关键词(KeyWords)： 肾功能衰竭,慢性;肾上腺髓质素;肾病;肾透析;顺应性;血管
kidney failure,chronic;adrenomedullin;nephrosis;renal dialysis;compliance;blood vessels

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刁晓艳,孙宁玲,于仲元
DIAO Xiao-yan~1,SUN Ning-ling~1,YU Zhong-yuan~2(1.Department of Cardiology

DOI: 10.19367/j.cnki.1000-2707.2005.06.013

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